Autonomic dysfunction and frailty in elderly: a systematic review and meta-analysis

Research output: Unpublished contribution to conferencePoster

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Abstract

Objectives: Autonomic dysfunction and frailty are two common and complex geriatric syndromes. Their prevalence increases with age and
they have similar negative health outcomes (increased morbidity and mortality). The aim was to systematically review the
current literature to determine the relationship between autonomic dysfunction and frailty.
Method: PubMed and Web of Science were screened (n=904) for studies reporting a relationship between autonomic function (AD) and frailty in elderly aged 65 and over(n=13). A meta-analysis (OpenMetaAnalyst) was performed for the articles measuring orthostatic hypotension (OH) (n=7). NIH quality assessment of included articles was performed.
Results: In a meta-analysis orthostatic hypotension was associated with a 2.45 higher risk for frailty (OR 95%CI[1.51–3.95]; 7 studies; n=3896 participants). Most studies in this systematic review observed an association between OH and frailty, Therefore, clinical measurements of Frailty in elderly should be followed by an autonomic stress test. Moreover, frail elderly presenting with OH might benefit from additional therapeutical strategies.
Conclusion: This systematic review shows a clear trend towards an association between frailty and autonomic dysfunction when measured as orthostatic hypotension (OH). Still, there is a great need for a golden standard and uniformization within emerging measurements of autonomic dysfunction. Interventions targeting OH could potentially benefit certain frail elderly as prospective studies should emerge.
Original languageEnglish
Pages1-1
Number of pages1
Publication statusPublished - 26 Feb 2021
EventBVGG-SBGG Wintermeeting 2021 - Online, Belgium
Duration: 26 Feb 202127 Feb 2021

Conference

ConferenceBVGG-SBGG Wintermeeting 2021
Country/TerritoryBelgium
Period26/02/2127/02/21

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