Behavioral effects of vigabatrin correlated with whole brain gamma-aminobutyric acid metabolism in audiogenic sensitive rats

S Engelborghs, BA Pickut, R D'Hooge, P Wiechert, K Haegele, PP De Deyn

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Abstract

The present study evaluates dose-dependent behavioral effects of acutely or subacutely administered single doses of vigabatrin (gamma-vinyl gamma-aminobutyric acid, gamma-vinyl GABA, CAS 60643-86-9) in audiogenic sensitive rats, in correlation with whole brain GABA metabolism. There was a discrepancy in timing between behaviorally observed maximal antiepileptic protection (4 h after i.p. administration of gamma-vinyl GABA) and on the other hand maximal inhibition of GABA-transaminase activity and maximal increase of whole brain GABA content (24 h after i.p. administration of gamma-vinyl GABA). This suggests that the antiepileptic properties of gamma-vinyl GABA not only depend on GABA-ergic neurotransmission. A possible explanation is a gamma-vinyl GABA-induced decrease of excitatory amino acids or increased glycine concentrations in the brain.
Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
Volume48
Issue number7
Publication statusPublished - Jul 1998

Keywords

  • gamma-aminobutyric acid
  • anticonvulsant
  • CAS 60643-86-9
  • vigabatrin, behavioral
  • effects, rat
  • gamma-vinyl gamma-aminobutyric acid

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