Binding domains directed against gpcr: g protein complexes and uses derived thereof

Jan Steyaert; Els Pardon; Toon Laeremans; Brian K Kobilka; Soren G. F. Rasmussen; Sebastien Granier; Roger K. Sunahara

Binding domains directed against gpcr: g protein complexes and uses derived thereof

Jan Steyaert (Inventor), Els Pardon (Inventor), Toon Laeremans (Inventor), Brian K Kobilka (Inventor), Soren G. F. Rasmussen (Inventor), Sebastien Granier (Inventor), Roger K. Sunahara (Inventor)

Research output: Patent

Abstract

The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

Original language	English
Patent number	EP2723764B
Priority date	21/06/11
Filing date	21/06/12
Publication status	Published - 27 Dec 2017

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title = "Binding domains directed against gpcr: g protein complexes and uses derived thereof",

abstract = "The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.",

author = "Jan Steyaert and Els Pardon and Toon Laeremans and Kobilka, {Brian K} and Rasmussen, {Soren G. F.} and Sebastien Granier and Sunahara, {Roger K.}",

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day = "27",

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T1 - Binding domains directed against gpcr: g protein complexes and uses derived thereof

AU - Steyaert, Jan

AU - Pardon, Els

AU - Laeremans, Toon

AU - Kobilka, Brian K

AU - Rasmussen, Soren G. F.

AU - Granier, Sebastien

AU - Sunahara, Roger K.

PY - 2017/12/27

Y1 - 2017/12/27

N2 - The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

AB - The present invention relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present invention relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present invention can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

UR - https://worldwide.espacenet.com/patent/search/family/047423019/publication/EP2723764B1?q=EP2723764

M3 - Patent

M1 - EP2723764B

Y2 - 2012/06/21

ER -

Binding domains directed against gpcr: g protein complexes and uses derived thereof

Abstract

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