Bioassay (CALUX) measurements of 2,3,7,8-TCDD and PCB 126: interference effects

Hermes Sanctorum-Vandevoorde, Marc Elskens, Willy Baeyens

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Interference effects in CALUX measurements were studied. 2,3,7,8-TCDD and PCB 126 solutions were added, according an experimental design, to the genetically modified cells. CALUX responses were measured for pure solutions of each of these pollutants, for mixtures of them and for successive additions where the first added pollutant is removed after 4h and replaced by medium solution, the same pollutant or the other one.
It appeared that in cases where the cells were exposed to TCDD and PCB 126 in series, additivity was obeyed. This was not the case when the pollutants were added to the cells simultaneously as these results show antagonistic effects.
Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalTalanta
Volume73
Publication statusPublished - 2007

Keywords

  • CALUX
  • 2,3,7,8-TCDD
  • PCB 126
  • antagonism

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