Biology and pathobiology of gap junctional channels in hepatocytes

Mathieu Vinken, Tom Henkens, Evelien De Rop, Joanna Fraczek, Tamara Vanhaecke, Vera Rogiers

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The present review provides the state of the art of the current knowledge concerning gap junctional channels and their roles in liver functioning. In the first part, we summarize some relevant biochemical properties of hepatic gap junctional channels, including their structure and regulation. In the second part, we discuss the involvement of gap junctional channels in the occurrence of liver cell growth, liver cell differentiation, and liver cell death. We further exemplify their relevance in hepatic pathophysiology. Finally, a number of directions for future liver gap junctional channel research are proposed, and the up-regulation of gap junctional channel activity as a novel strategy in (liver) cancer therapy is illustrated.
Original languageEnglish
Pages (from-to)1077-1088
Number of pages11
JournalHepatology
Volume47
Publication statusPublished - 5 Feb 2008

Keywords

  • liver homeostasis
  • hepatocyte
  • connexin
  • gap junction

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