Biomarkers of aging for the identification and evaluation of longevity interventions

Biomarkers of Aging Consortium

doi:10.1016/j.cell.2023.08.003

Biomarkers of aging for the identification and evaluation of longevity interventions

Biomarkers of Aging Consortium

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

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Abstract

With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

Original language	English
Pages (from-to)	3758-3775
Number of pages	18
Journal	Cell
Volume	186
Issue number	18
DOIs	https://doi.org/10.1016/j.cell.2023.08.003
Publication status	Published - 31 Aug 2023

Bibliographical note

Keywords

Humans
Longevity
Aging
Biomarkers

Access to Document

10.1016/j.cell.2023.08.003

110029488Accepted author manuscript, 2.66 MBLicence: CC BY-NC-ND

Cite this

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title = "Biomarkers of aging for the identification and evaluation of longevity interventions",

abstract = "With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.",

keywords = "Humans, Longevity, Aging, Biomarkers",

author = "{Biomarkers of Aging Consortium} and Mahdi Moqri and Chiara Herzog and Poganik, {Jesse R} and Jamie Justice and Belsky, {Daniel W} and Albert Higgins-Chen and Alexey Moskalev and Georg Fuellen and Cohen, {Alan A} and Ivan Bautmans and Martin Widschwendter and Jingzhong Ding and Alexander Fleming and Joan Mannick and Han, {Jing-Dong Jackie} and Alex Zhavoronkov and Nir Barzilai and Matt Kaeberlein and Steven Cummings and Kennedy, {Brian K} and Luigi Ferrucci and Steve Horvath and Eric Verdin and Maier, {Andrea B} and Snyder, {Michael P} and Vittorio Sebastiano and Gladyshev, {Vadim N}",

year = "2023",

month = aug,

day = "31",

doi = "10.1016/j.cell.2023.08.003",

language = "English",

volume = "186",

pages = "3758--3775",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "18",

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TY - JOUR

T1 - Biomarkers of aging for the identification and evaluation of longevity interventions

AU - Biomarkers of Aging Consortium

AU - Moqri, Mahdi

AU - Herzog, Chiara

AU - Poganik, Jesse R

AU - Justice, Jamie

AU - Belsky, Daniel W

AU - Higgins-Chen, Albert

AU - Moskalev, Alexey

AU - Fuellen, Georg

AU - Cohen, Alan A

AU - Bautmans, Ivan

AU - Widschwendter, Martin

AU - Ding, Jingzhong

AU - Fleming, Alexander

AU - Mannick, Joan

AU - Han, Jing-Dong Jackie

AU - Zhavoronkov, Alex

AU - Barzilai, Nir

AU - Kaeberlein, Matt

AU - Cummings, Steven

AU - Kennedy, Brian K

AU - Ferrucci, Luigi

AU - Horvath, Steve

AU - Verdin, Eric

AU - Maier, Andrea B

AU - Snyder, Michael P

AU - Sebastiano, Vittorio

AU - Gladyshev, Vadim N

PY - 2023/8/31

Y1 - 2023/8/31

N2 - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

AB - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

KW - Humans

KW - Longevity

KW - Aging

KW - Biomarkers

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U2 - 10.1016/j.cell.2023.08.003

DO - 10.1016/j.cell.2023.08.003

M3 - Article

C2 - 37657418

VL - 186

SP - 3758

EP - 3775

JO - Cell

JF - Cell

SN - 0092-8674

IS - 18

ER -

Biomarkers of aging for the identification and evaluation of longevity interventions

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

IRP22: The Gerontopole Brussels - Centre of expertise for Gerontology at the Vrije Universiteit Brussel - Central theme: Active & Healthy Ageing

SRP59: SRP-Groeifinanciering: Physical exercise to counteract inflammation in ageing

OZR4026: ERC connect funding: CLIP-EX: Countering chronic Low-grade Inflammation by Physical Exercise: unraveling muscle–to-immune-cell communication

Cite this

Biomarkers of aging for the identification and evaluation of longevity interventions

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Projects

IRP22: The Gerontopole Brussels - Centre of expertise for Gerontology at the Vrije Universiteit Brussel - Central theme: Active & Healthy Ageing

SRP59: SRP-Groeifinanciering: Physical exercise to counteract inflammation in ageing

OZR4026: ERC connect funding: CLIP-EX: Countering chronic Low-grade Inflammation by Physical Exercise: unraveling muscle–to-immune-cell communication

Cite this