TY - JOUR
T1 - Bronsted Acid-Catalyzed Enantioselective Iodocycloetherification Enable by triphenylphosphine selenide Cocatalysis
AU - Guria, Sudip
AU - Daniliuc, Constantin G.
AU - Hennecke, Ulrich
PY - 2021/7/6
Y1 - 2021/7/6
N2 - Enantioselective iodocycloetherifications can be conducted using sterically highly demanding BINOL-based phosphoric acid diesters as catalyst. To achieve highly enantioselective reactions, cocatalysis by triphenylphosphine selenide is necessary. With cocatalysis, good to excellent enantioselectivities can be achieved for a broad range of substrates using catalyst and cocatalyst loadings as low as 1 mol %. The triphenylphosphine selenide cocatalyst itself does not strongly influence diastereoselectivity, but leads to higher reactivity and, in combination with a BINOL-based phosphoric acid diester, to good enantioselectivity. (Figure presented.).
AB - Enantioselective iodocycloetherifications can be conducted using sterically highly demanding BINOL-based phosphoric acid diesters as catalyst. To achieve highly enantioselective reactions, cocatalysis by triphenylphosphine selenide is necessary. With cocatalysis, good to excellent enantioselectivities can be achieved for a broad range of substrates using catalyst and cocatalyst loadings as low as 1 mol %. The triphenylphosphine selenide cocatalyst itself does not strongly influence diastereoselectivity, but leads to higher reactivity and, in combination with a BINOL-based phosphoric acid diester, to good enantioselectivity. (Figure presented.).
UR - http://www.scopus.com/inward/record.url?scp=85109757816&partnerID=8YFLogxK
U2 - 10.1002/adsc.202100605
DO - 10.1002/adsc.202100605
M3 - Article
SN - 1615-4169
VL - 363
SP - 3852
EP - 3858
JO - Advanced Synthesis & Catalysis
JF - Advanced Synthesis & Catalysis
IS - 15
ER -