Brugada Syndrome and Early Repolarisation: Distinct Clinical Entities or Different Phenotypes of the Same Genetic Disease?

Giulio Conte, Maria Luce Caputo, François Regoli, Tiziano Moccetti, Pedro Brugada, Angelo Auricchio

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Brugada and early repolarisation (ER) syndromes are currently considered two distinct inherited electrical disorders with overlapping clinical and electrocardiographic features. A considerable number of patients diagnosed with ER syndrome have a genetic mutation related to Brugada syndrome (BrS). Due to the high variable phenotypic manifestation, patients with BrS may present with inferolateral repolarisation abnormalities only, resembling the ER pattern. Moreover, the complex genotype-phenotype interaction in BrS can lead to the occurrence of mixed phenotypes with ER syndrome. The first part of this review focuses on specific clinical and electrocardiographic features of BrS and ER syndrome, highlighting the similarity shared by the two primary electrical disorders. The genetic background, with emphasis on the complexity of genotype-phenotype interaction, is explored in the second part of this review.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalCirculation: Arrhythmia and Electrophysiology
Volume5
Issue number2
DOIs
Publication statusPublished - Aug 2016

Keywords

  • Brugada Syndrome
  • early repolarisation
  • Electrocardiogram
  • genotype
  • phenotype
  • sudden cardiac death
  • ventricular arrthythmias

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