C075 - Inflammatory signaling pathways up-regulate the cystine/glutamate antiporter system xc- in cortical murine astrocytes in vitro and in the brain in vivo

Timo-Daniel Voss, Jan Lewerenz, Frederic Appelt, Richard Klaus, Sato Hideyo, Giulia Albertini, Ilse Smolders, Ann Massie

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract (Book)

Abstract

Inflammatory stimuli upregulate system xc- in vivo and in vitro. This is mediated by increased transcription of xCT, the specific subunit of system xc-. Counterintuitively, NFκB might rather represent an inhibitory feedback loop in the inflammatory induction of system xc-downstream of inflammatory pathways
Original languageEnglish
Title of host publicationFederation of European Neuroscience Society, 11th FENS Forum of Neuroscience, Berlin, 7-11 july 2018
Number of pages1
Publication statusPublished - 2018
Event11th FENS Forum of Neuroscience - Berlin, Germany
Duration: 7 Jul 201811 Jul 2018

Conference

Conference11th FENS Forum of Neuroscience
CountryGermany
CityBerlin
Period7/07/1811/07/18

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