Cardiovascular determinants and prognostic significance of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary artery

Johan De Sutter, Sofie Struyf, Nico Van De Veire, J. Philippe, M. De Buyzere, J. Van Damme

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Chemokines are important mediators of angiogenesis, hematopoiesis and leucocyte trafficking. CC Chemokine Ligand-18 (CCL18)/ pulmonary and activation-regulated chemokine (PARC) is a circulating chemokine that plays a role in injury healing, physiological homing of mononuclear blood cells and inflammatory responses. CCL18/PARC is also expressed in atherosclerotic plaques. We prospectively evaluated CCL18/PARC levels and their cardiovascular and biological determinants in a large cohort of 285 patients with stable coronary heart disease who were subsequently followed for 3 years for hard cardiac events. It was found that CCL18/PARC levels were associated with decreased cardiac function, decreased exercise capacity and increased inflammatory parameters including interleukin-6 (IL-6) and hs-CRP. More importantly high CCL18/PARC levels were an independent predictor of future cardiovascular events. Therefore, CCL18/PARC is a potential diagnostic and prognostic parameter in patients with stable coronary artery disease.
Original languageEnglish
Pages (from-to)894-896
Number of pages3
JournalJournal of Molecular and Cellular Cardiology
Volume49
Issue number5
Publication statusPublished - Nov 2010

Keywords

  • chemokines
  • Human stable coronary artery disease
  • Cardiac function
  • Exercise capacity
  • Interleukin-6
  • Prognosis

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