Abstract
Chemokines are important mediators of angiogenesis, hematopoiesis and leucocyte trafficking. CC Chemokine Ligand-18 (CCL18)/ pulmonary and activation-regulated chemokine (PARC) is a circulating chemokine that plays a role in injury healing, physiological homing of mononuclear blood cells and inflammatory responses. CCL18/PARC is also expressed in atherosclerotic plaques. We prospectively evaluated CCL18/PARC levels and their cardiovascular and biological determinants in a large cohort of 285 patients with stable coronary heart disease who were subsequently followed for 3 years for hard cardiac events. It was found that CCL18/PARC levels were associated with decreased cardiac function, decreased exercise capacity and increased inflammatory parameters including interleukin-6 (IL-6) and hs-CRP. More importantly high CCL18/PARC levels were an independent predictor of future cardiovascular events. Therefore, CCL18/PARC is a potential diagnostic and prognostic parameter in patients with stable coronary artery disease.
| Original language | English |
|---|---|
| Pages (from-to) | 894-896 |
| Number of pages | 3 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 49 |
| Issue number | 5 |
| Publication status | Published - Nov 2010 |
Keywords
- chemokines
- Human stable coronary artery disease
- Cardiac function
- Exercise capacity
- Interleukin-6
- Prognosis