Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein

Olga Rusyakina; Thomas Geernaert; Médéric Loyez; Maxime  Lobry; Karima Chah; Pawel Mergo; Hugo Thienpont; Christophe Caucheteur; Francis Berghmans; Tigran Baghdasaryan

doi:10.1016/j.snb.2023.133561

Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein

Olga Rusyakina, Thomas Geernaert, Médéric Loyez, Maxime Lobry, Karima Chah, Pawel Mergo, Hugo Thienpont, Christophe Caucheteur, Francis Berghmans, Tigran Baghdasaryan

Research output: Contribution to journal › Article › peer-review

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Abstract

Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.

Original language	English
Article number	133561
Pages (from-to)	1-10
Number of pages	10
Journal	Sensors and Actuators B: Chemical
Volume	382
DOIs	https://doi.org/10.1016/j.snb.2023.133561
Publication status	Published - 1 May 2023

Bibliographical note

Funding Information:
This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). The approach for an external refractometry and biosensing with PCFs with their multiplexing capability has been published on April 7th, 2022, as a patent application entitled “Microstructured optical fiber sensing device” under an international publication number WO 2022/069687 A1. Supplementary data. The file with supplementary data is available online.

Funding Information:
This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem ; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS).

Publisher Copyright:
© 2023

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

Keywords

sensor multiplexing
photonic crystal fiber
fiber Bragg grating
surface plasmon resonance
HER2 detection
fiber optic biosensor

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10.1016/j.snb.2023.133561Licence: CC BY

2023 - O. Rusyakina - Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 proteinFinal published version, 4.92 MBLicence: CC BY

Cite this

Rusyakina, Olga ; Geernaert, Thomas ; Loyez, Médéric ; Lobry, Maxime ; Chah, Karima ; Mergo, Pawel ; Thienpont, Hugo ; Caucheteur, Christophe ; Berghmans, Francis ; Baghdasaryan, Tigran. / Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein. In: Sensors and Actuators B: Chemical. 2023 ; Vol. 382. pp. 1-10.

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title = "Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein",

abstract = "Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.",

keywords = "sensor multiplexing, photonic crystal fiber, fiber Bragg grating, surface plasmon resonance, HER2 detection, fiber optic biosensor",

author = "Olga Rusyakina and Thomas Geernaert and M{\'e}d{\'e}ric Loyez and Maxime Lobry and Karima Chah and Pawel Mergo and Hugo Thienpont and Christophe Caucheteur and Francis Berghmans and Tigran Baghdasaryan",

note = "Funding Information: This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). The approach for an external refractometry and biosensing with PCFs with their multiplexing capability has been published on April 7th, 2022, as a patent application entitled “Microstructured optical fiber sensing device” under an international publication number WO 2022/069687 A1. Supplementary data. The file with supplementary data is available online. Funding Information: This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem ; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). Publisher Copyright: {\textcopyright} 2023 Copyright: Copyright 2023 Elsevier B.V., All rights reserved.",

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Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein. / Rusyakina, Olga; Geernaert, Thomas; Loyez, Médéric; Lobry, Maxime; Chah, Karima; Mergo, Pawel; Thienpont, Hugo; Caucheteur, Christophe; Berghmans, Francis ; Baghdasaryan, Tigran.

In: Sensors and Actuators B: Chemical, Vol. 382, 133561, 01.05.2023, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein

AU - Rusyakina, Olga

AU - Geernaert, Thomas

AU - Loyez, Médéric

AU - Lobry, Maxime

AU - Chah, Karima

AU - Mergo, Pawel

AU - Thienpont, Hugo

AU - Caucheteur, Christophe

AU - Berghmans, Francis

AU - Baghdasaryan, Tigran

N1 - Funding Information: This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). The approach for an external refractometry and biosensing with PCFs with their multiplexing capability has been published on April 7th, 2022, as a patent application entitled “Microstructured optical fiber sensing device” under an international publication number WO 2022/069687 A1. Supplementary data. The file with supplementary data is available online. Funding Information: This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem ; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). Publisher Copyright: © 2023 Copyright: Copyright 2023 Elsevier B.V., All rights reserved.

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.

AB - Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.

KW - sensor multiplexing

KW - photonic crystal fiber

KW - fiber Bragg grating

KW - surface plasmon resonance

KW - HER2 detection

KW - fiber optic biosensor

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U2 - 10.1016/j.snb.2023.133561

DO - 10.1016/j.snb.2023.133561

M3 - Article

VL - 382

SP - 1

EP - 10

JO - Sensors and Actuators. B, Chemical

JF - Sensors and Actuators. B, Chemical

SN - 0925-4005

M1 - 133561

ER -

Cascaded Bragg gratings in photonic crystal fiber for plasmonic cladding mode-based biosensing of HER2 protein

Abstract

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Keywords

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