Central and Peripheral Muscle Fatigue in Hopsitalized Geriatric Patients versus Elderly Controls

Research output: Contribution to journalMeeting abstract (Journal)

Abstract

Purpose:To identify central and peripheral muscle activation deficits in inflammation-induced muscle fatigue.

Methods: Hospitalized geriatric patients (N=10) and elderly community-dwelling controls (N=18) performed a sustained maximal isometric contraction of the M. Adductor Pollicis until the strength dropped to 50% of its maximal value. Voluntary muscle activation was studied before and at the end of the fatigue test using the twitch interpolation method (by stimulation of the Ulnar Nerve). Muscle activity was continuously monitored using surface (s)EMG. Circulating levels of pro- and anti-inflammatory cytokines/chemokines were analyzed.

Results: We found no significant difference in central muscular activation between both groups. Geriatric patients showed a significant (p
Conclusions: Inflammation-induced muscle fatigue is probably due to local processes, acting at the level of the muscle itself. Further studies are required to unravel the exact pathways involved.
Original languageEnglish
Pages (from-to)43
Number of pages1
JournalTijdschrift voor Gerontologie en Geriatrie
Volume43
Publication statusPublished - 2 Feb 2012

Keywords

  • Frailty
  • SARCOPENIA
  • INFLAMMATION
  • sEMG

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