Changes in glial glutamate transporters protein levels in TMEV model of viral-induced epilepsy - XIIth European Meeting on glial cell function in health and disease, Bilbao, Spain, july 15-18, 2015

Giulia Albertini, Shawn Loewen, Joeri Van Liefferinge, Eduard Mihai Bentea, Thomas Demuyser, Ellen Merckx, Lauren Deneyer, Ilse Julia Smolders, Karen Wilcox, Ann Massie

Research output: Contribution to journalMeeting abstract (Journal)

Abstract

Viral encephalitis is often associated with seizures and increased risk of developing chronic epilepsy. Intracerebral (i.c) infections of Daniel (DA) strain of Theiler’s murine encephalomyelitis virus (TMEV) in susceptible strains of mice cause acute encephalitis followed by a chronic inflammatory demyelinating disease with persistence of the virus (Sato et al., Pathophysiology. 18(1): 31-41, 2011). Recently it has been shown that C57BL/6 (B6) mice are resistant to TMEV-induced demyelination and, after developing an acute disease characterized by tonic-clonic seizures, are able to clear the virus within 2 weeks post-infection (p.i.). Interestingly, TMEV infection chronically alters seizure susceptibility and a significant proportion of mice develop spontaneous seizures, establishing the TMEV model in B6 mice as a valid model of viral-induced epilepsy
Original languageEnglish
Article numberT15-01A
Pages (from-to)E443-E444
Number of pages2
JournalGlia
Volume63
Publication statusPublished - Aug 2015
EventXIIth European Meeting on glial cell function in health and disease, Bilbao, Spain, july 15-18, 2015 - Bilbao, Spain
Duration: 15 Jul 201518 Jul 2015

Keywords

  • glial glutamate

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