Characterization of Bordetella pertussis clinical isolates that do not express the tracheal colonization factor.

Marjolein Van Gent, Denis Pierard, Sabine Lauwers, Hg Van Der Heide, Aj King, Fr Mooi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bordetella pertussis, the causative agent of whooping cough, has remained endemic
and there is a resurgence in some countries despite vaccination. Bordetella
pertussis produces a wide range of virulence factors which are assumed to play an
important role in infection and transmission, including tracheal colonization
factor (TcfA). Here we show that clinical isolates belonging to distinct lineages
may lose their ability to produce TcfA. Irreversible and reversible loss
occurred, respectively, by recombination between repeats leading to deletion of
the tcfA gene and by mutations in a polymorphic G-track. These phenomena may
reflect adaptation to distinct niches.
Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalFEMS Immunol Med Microbiol
Volume51
Publication statusPublished - Oct 2007

Keywords

  • pertussis
  • bordetella

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