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Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.

Original languageEnglish
Article number105422
Number of pages11
JournalEnvironment International
Early online dateMar 2020
Publication statusPublished - Mar 2020

Bibliographical note

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.


  • Cholestasis
  • Food additives
  • Dietary Supplements
  • Herbal supplements
  • Parenteral Nutrition

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