Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Vânia Vilas-Boas; Eva Gijbels; Joop Jonckheer; Elisabeth De Waele; Mathieu Vinken

doi:10.1016/j.envint.2019.105422

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Vânia Vilas-Boas, Eva Gijbels, Joop Jonckheer, Elisabeth De Waele, Mathieu Vinken

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Abstract

Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.

Original language	English
Article number	105422
Number of pages	11
Journal	Environment International
Volume	136
Early online date	Mar 2020
DOIs	https://doi.org/10.1016/j.envint.2019.105422
Publication status	Published - Mar 2020

Bibliographical note

Keywords

Cholestasis
Food additives
Dietary Supplements
Herbal supplements
Parenteral Nutrition

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10.1016/j.envint.2019.105422Licence: CC BY

paperFinal published version, 1.73 MBLicence: CC BY

Cite this

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title = "Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition",

abstract = "Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.",

keywords = "Cholestasis, Food additives, Dietary Supplements, Herbal supplements, Parenteral Nutrition",

author = "V{\^a}nia Vilas-Boas and Eva Gijbels and Joop Jonckheer and {De Waele}, Elisabeth and Mathieu Vinken",

year = "2020",

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doi = "10.1016/j.envint.2019.105422",

language = "English",

volume = "136",

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T1 - Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

AU - Vilas-Boas, Vânia

AU - Gijbels, Eva

AU - Jonckheer, Joop

AU - De Waele, Elisabeth

AU - Vinken, Mathieu

PY - 2020/3

Y1 - 2020/3

N2 - Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.

AB - Cholestasis refers to the accumulation of toxic levels of bile acids in the liver due to defective bile secretion. This pathological situation can be triggered by drugs, but also by ingredients contained in food, food supplements and parenteral nutrition. This paper provides an overview of the current knowledge on cholestatic injury associated with such ingredients, with particular emphasis on the underlying mechanisms of toxicity.

KW - Cholestasis

KW - Food additives

KW - Dietary Supplements

KW - Herbal supplements

KW - Parenteral Nutrition

UR - https://www.sciencedirect.com/science/article/pii/S0160412019334610?via%3Dihub

U2 - 10.1016/j.envint.2019.105422

DO - 10.1016/j.envint.2019.105422

M3 - Article

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SN - 0160-4120

VL - 136

JO - Environment International

JF - Environment International

M1 - 105422

ER -

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

EU604: ChOLLATERAL: Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals.

Cite this

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Projects

EU604: ChOLLATERAL: Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals.

Cite this