Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach

Geir Bjørklund, Maryam Dadar, Joeri J Pen, Salvatore Chirumbolo, Jan Aaseth

Research output: Contribution to journalScientific reviewpeer-review

45 Citations (Scopus)


Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. In this review, we focus on the nutritional intervention in CFS, discussing the many immunological, environmental, and nutritional aspects currently investigated about this disease. Changes in immunoglobulin levels, cytokine profiles and B- and T- cell phenotype and declined cytotoxicity of natural killer cells, are commonly reported features of immune dysregulation in CFS. Also, some nutrient deficiencies (vitamin C, vitamin B complex, sodium, magnesium, zinc, folic acid, l-carnitine, l-tryptophan, essential fatty acids, and coenzyme Q10) appear to be important in the severity and exacerbation of CFS symptoms. This review highlights a far-driven analysis of mineral and vitamin deficiencies among CFS patients.

Original languageEnglish
Pages (from-to)1000-1007
Number of pages8
JournalBiomedicine & Pharmacotherapy
Publication statusPublished - Jan 2019

Bibliographical note

Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.


  • Cytokines/immunology
  • Dietary Supplements
  • Fatigue Syndrome, Chronic/diet therapy
  • Gastrointestinal Microbiome/drug effects
  • Humans
  • Nutrients/administration & dosage
  • Oxidative Stress/drug effects
  • T-Lymphocytes/drug effects


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