Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

Milca Asanghanwa, Frans Gorus, Ilse Weets, Bart Van Der Auwera, Folefac Aminkeng, Eric Mbunwe, Patrick Goubert, Katrijn Verhaeghen, Eugène Sobngwi, J. Wenzlau, J.c. Hutton, Daniel Pipeleers, Bart Keymeulen, Jean-Claude Mbanya, Christiaan Van Schravendijk

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

AIMS:

We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium.

METHODS:

Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years.

RESULTS:

Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody vs 9% in healthy controls (24% vs 7% for GADA (p
CONCLUSIONS:

In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalDiabetes Res Clin Pract
Volume103
Publication statusPublished - 2014

Keywords

  • autoantibodies
  • classification
  • diabetes

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