Clinical characterisation and long-term prognosis of women with Brugada syndrome

Juan Sieira; Giulio Conte; Giuseppe Ciconte; Carlo de Asmundis; Giannis Baltogiannis; Giacomo Di Giovanni; Yukio Saitoh; Ghazala Irfan; Ruben Casado-Arroyo; Justo Juliá; Mark La Meir; Francis Wellens; Kristel Wauters; Gudrun Pappaert; Pedro Brugada; Jean-Baptiste Chierchia

doi:10.1136/heartjnl-2015-308556

Clinical characterisation and long-term prognosis of women with Brugada syndrome

Juan Sieira, Giulio Conte, Giuseppe Ciconte, Carlo de Asmundis, Giannis Baltogiannis, Giacomo Di Giovanni, Yukio Saitoh, Ghazala Irfan, Ruben Casado-Arroyo, Justo Juliá, Mark La Meir, Francis Wellens, Kristel Wauters, Gudrun Pappaert, Pedro Brugada, Jean-Baptiste Chierchia

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

OBJECTIVES: Brugada syndrome (BS) in women is considered an infrequent condition with a more favourable prognosis than in men. Nevertheless, arrhythmic events and sudden cardiac death (SCD) also occur in this population. Long-term follow-up data of this group are sparse. The purpose of the present study was to investigate the clinical characteristics and long-term prognosis of women with BS.

METHODS: A consecutive cohort of 228 women presenting with spontaneous or drug-induced Brugada type I ECG at our institution were included and compared with 314 men with the same diagnosis.

RESULTS: Mean age was 41.5±17.3 years. Clinical presentation was SCD in 6 (2.6%), syncope in 51 (22.4%) and the remaining 171 (75.0%) were asymptomatic. As compared with men, spontaneous type I ECG was less common (7.9% vs 23.2%, p<0.01) and less ventricular arrhythmias were induced during programmed electrical stimulation (5.5% vs 22.3%, p<0.01). An implantable cardioverter defibrillator (ICD) was implanted in 64 women (28.1%). During a mean follow-up of 73.2±56.2 months, seven patients developed arrhythmic events, constituting an event rate of 0.7% per year (as compared with 1.9% per year in men, p=0.02). Presentation as SCD or sinus node dysfunction (SND) was risk factor significantly associated with arrhythmic events (hazard risk (HR) 25.4 and 9.1).

CONCLUSION: BS is common in women, representing 42% of patients in our database. Clinical presentation is less severe than men, with more asymptomatic status and less spontaneous type I ECG and prognosis is more favourable, with an event rate of 0.7% year. However, women with SCD or previous SND are at higher risk of arrhythmic events.

Original language	English
Pages (from-to)	452-458
Number of pages	7
Journal	Heart
Volume	102
Issue number	6
DOIs	https://doi.org/10.1136/heartjnl-2015-308556
Publication status	Published - Mar 2016

Keywords

Brugada syndrome
women
sudden cardiac death

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10.1136/heartjnl-2015-308556

IRP8_a: IMAGica: an Integrative personalised Medical Approach for Genetic diseases, Inherited Cardiac Arrhythmias as a model
Nowe, A., Bonduelle, M., Brugada, P., Deschepper, R., Lenaerts, T., Van Dooren, S., De Asmundis, C., Gidron, Y., Bilsen, J. & De Couck, M.
1/07/16 → 30/06/23
Project: Fundamental

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Sieira, J., Conte, G., Ciconte, G., de Asmundis, C., Baltogiannis, G., Di Giovanni, G., Saitoh, Y., Irfan, G., Casado-Arroyo, R., Juliá, J., La Meir, M., Wellens, F., Wauters, K., Pappaert, G., Brugada, P., & Chierchia, J-B. (2016). Clinical characterisation and long-term prognosis of women with Brugada syndrome. Heart, 102(6), 452-458. https://doi.org/10.1136/heartjnl-2015-308556

Sieira, Juan ; Conte, Giulio ; Ciconte, Giuseppe ; de Asmundis, Carlo ; Baltogiannis, Giannis ; Di Giovanni, Giacomo ; Saitoh, Yukio ; Irfan, Ghazala ; Casado-Arroyo, Ruben ; Juliá, Justo ; La Meir, Mark ; Wellens, Francis ; Wauters, Kristel ; Pappaert, Gudrun ; Brugada, Pedro ; Chierchia, Jean-Baptiste. / Clinical characterisation and long-term prognosis of women with Brugada syndrome. In: Heart. 2016 ; Vol. 102, No. 6. pp. 452-458.

@article{6678c2dd4038462cbfcf65a88928b0e6,

title = "Clinical characterisation and long-term prognosis of women with Brugada syndrome",

abstract = "OBJECTIVES: Brugada syndrome (BS) in women is considered an infrequent condition with a more favourable prognosis than in men. Nevertheless, arrhythmic events and sudden cardiac death (SCD) also occur in this population. Long-term follow-up data of this group are sparse. The purpose of the present study was to investigate the clinical characteristics and long-term prognosis of women with BS.METHODS: A consecutive cohort of 228 women presenting with spontaneous or drug-induced Brugada type I ECG at our institution were included and compared with 314 men with the same diagnosis.RESULTS: Mean age was 41.5±17.3 years. Clinical presentation was SCD in 6 (2.6%), syncope in 51 (22.4%) and the remaining 171 (75.0%) were asymptomatic. As compared with men, spontaneous type I ECG was less common (7.9% vs 23.2%, p<0.01) and less ventricular arrhythmias were induced during programmed electrical stimulation (5.5% vs 22.3%, p<0.01). An implantable cardioverter defibrillator (ICD) was implanted in 64 women (28.1%). During a mean follow-up of 73.2±56.2 months, seven patients developed arrhythmic events, constituting an event rate of 0.7% per year (as compared with 1.9% per year in men, p=0.02). Presentation as SCD or sinus node dysfunction (SND) was risk factor significantly associated with arrhythmic events (hazard risk (HR) 25.4 and 9.1).CONCLUSION: BS is common in women, representing 42% of patients in our database. Clinical presentation is less severe than men, with more asymptomatic status and less spontaneous type I ECG and prognosis is more favourable, with an event rate of 0.7% year. However, women with SCD or previous SND are at higher risk of arrhythmic events.",

keywords = "Brugada syndrome, women, sudden cardiac death",

author = "Juan Sieira and Giulio Conte and Giuseppe Ciconte and {de Asmundis}, Carlo and Giannis Baltogiannis and {Di Giovanni}, Giacomo and Yukio Saitoh and Ghazala Irfan and Ruben Casado-Arroyo and Justo Juli{\'a} and {La Meir}, Mark and Francis Wellens and Kristel Wauters and Gudrun Pappaert and Pedro Brugada and Jean-Baptiste Chierchia",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",

year = "2016",

month = mar,

doi = "10.1136/heartjnl-2015-308556",

language = "English",

volume = "102",

pages = "452--458",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "6",

}

Sieira, J, Conte, G, Ciconte, G, de Asmundis, C, Baltogiannis, G, Di Giovanni, G, Saitoh, Y, Irfan, G, Casado-Arroyo, R, Juliá, J, La Meir, M , Wellens, F , Wauters, K , Pappaert, G , Brugada, P & Chierchia, J-B 2016, 'Clinical characterisation and long-term prognosis of women with Brugada syndrome', Heart, vol. 102, no. 6, pp. 452-458. https://doi.org/10.1136/heartjnl-2015-308556

Clinical characterisation and long-term prognosis of women with Brugada syndrome. / Sieira, Juan; Conte, Giulio; Ciconte, Giuseppe; de Asmundis, Carlo; Baltogiannis, Giannis; Di Giovanni, Giacomo; Saitoh, Yukio; Irfan, Ghazala; Casado-Arroyo, Ruben; Juliá, Justo; La Meir, Mark ; Wellens, Francis ; Wauters, Kristel ; Pappaert, Gudrun ; Brugada, Pedro ; Chierchia, Jean-Baptiste.

In: Heart, Vol. 102, No. 6, 03.2016, p. 452-458.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical characterisation and long-term prognosis of women with Brugada syndrome

AU - Sieira, Juan

AU - Conte, Giulio

AU - Ciconte, Giuseppe

AU - de Asmundis, Carlo

AU - Baltogiannis, Giannis

AU - Di Giovanni, Giacomo

AU - Saitoh, Yukio

AU - Irfan, Ghazala

AU - Casado-Arroyo, Ruben

AU - Juliá, Justo

AU - La Meir, Mark

AU - Wellens, Francis

AU - Wauters, Kristel

AU - Pappaert, Gudrun

AU - Brugada, Pedro

AU - Chierchia, Jean-Baptiste

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2016/3

Y1 - 2016/3

N2 - OBJECTIVES: Brugada syndrome (BS) in women is considered an infrequent condition with a more favourable prognosis than in men. Nevertheless, arrhythmic events and sudden cardiac death (SCD) also occur in this population. Long-term follow-up data of this group are sparse. The purpose of the present study was to investigate the clinical characteristics and long-term prognosis of women with BS.METHODS: A consecutive cohort of 228 women presenting with spontaneous or drug-induced Brugada type I ECG at our institution were included and compared with 314 men with the same diagnosis.RESULTS: Mean age was 41.5±17.3 years. Clinical presentation was SCD in 6 (2.6%), syncope in 51 (22.4%) and the remaining 171 (75.0%) were asymptomatic. As compared with men, spontaneous type I ECG was less common (7.9% vs 23.2%, p<0.01) and less ventricular arrhythmias were induced during programmed electrical stimulation (5.5% vs 22.3%, p<0.01). An implantable cardioverter defibrillator (ICD) was implanted in 64 women (28.1%). During a mean follow-up of 73.2±56.2 months, seven patients developed arrhythmic events, constituting an event rate of 0.7% per year (as compared with 1.9% per year in men, p=0.02). Presentation as SCD or sinus node dysfunction (SND) was risk factor significantly associated with arrhythmic events (hazard risk (HR) 25.4 and 9.1).CONCLUSION: BS is common in women, representing 42% of patients in our database. Clinical presentation is less severe than men, with more asymptomatic status and less spontaneous type I ECG and prognosis is more favourable, with an event rate of 0.7% year. However, women with SCD or previous SND are at higher risk of arrhythmic events.

AB - OBJECTIVES: Brugada syndrome (BS) in women is considered an infrequent condition with a more favourable prognosis than in men. Nevertheless, arrhythmic events and sudden cardiac death (SCD) also occur in this population. Long-term follow-up data of this group are sparse. The purpose of the present study was to investigate the clinical characteristics and long-term prognosis of women with BS.METHODS: A consecutive cohort of 228 women presenting with spontaneous or drug-induced Brugada type I ECG at our institution were included and compared with 314 men with the same diagnosis.RESULTS: Mean age was 41.5±17.3 years. Clinical presentation was SCD in 6 (2.6%), syncope in 51 (22.4%) and the remaining 171 (75.0%) were asymptomatic. As compared with men, spontaneous type I ECG was less common (7.9% vs 23.2%, p<0.01) and less ventricular arrhythmias were induced during programmed electrical stimulation (5.5% vs 22.3%, p<0.01). An implantable cardioverter defibrillator (ICD) was implanted in 64 women (28.1%). During a mean follow-up of 73.2±56.2 months, seven patients developed arrhythmic events, constituting an event rate of 0.7% per year (as compared with 1.9% per year in men, p=0.02). Presentation as SCD or sinus node dysfunction (SND) was risk factor significantly associated with arrhythmic events (hazard risk (HR) 25.4 and 9.1).CONCLUSION: BS is common in women, representing 42% of patients in our database. Clinical presentation is less severe than men, with more asymptomatic status and less spontaneous type I ECG and prognosis is more favourable, with an event rate of 0.7% year. However, women with SCD or previous SND are at higher risk of arrhythmic events.

KW - Brugada syndrome

KW - women

KW - sudden cardiac death

U2 - 10.1136/heartjnl-2015-308556

DO - 10.1136/heartjnl-2015-308556

M3 - Article

C2 - 26740482

VL - 102

SP - 452

EP - 458

JO - Heart

JF - Heart

SN - 1355-6037

IS - 6

ER -

Clinical characterisation and long-term prognosis of women with Brugada syndrome

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Keywords

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IRP8_a: IMAGica: an Integrative personalised Medical Approach for Genetic diseases, Inherited Cardiac Arrhythmias as a model

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