Combined effects of tDCS over the left DLPFC and gaze-contingent training on attention mechanisms of emotion regulation in low-resilient individuals

Alvaro Sanchez-Lopez, Rudi De Raedt, Louise Puttevils, Ernst H W Koster, Chris Baeken, Marie-Anne Vanderhasselt

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Low resilience is characterized by impairments in attention and emotion regulation mechanisms that depend on prefrontal cortical activity. The aim of this study was to test whether transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) can augment the effectiveness of a new computerized mouse-based (gaze)contingent training (MCAT) to improve attention and emotion regulation processes (improved reappraisal, reduced rumination) in individuals reporting low resilience levels. The study used a full-factorial between-subject design combining active and sham MCAT and tDCS interventions. One hundred participants reporting low resilience levels were randomly assigned to receive either a single session of: tDCS with sham MCAT treatment (tDCS group), MCAT with sham tDCS (MCAT group), a combination of tDCS and MCAT (combined group), or sham tDCS and sham MCAT (control group). Transfer to attention regulation, reappraisal success, and state rumination was evaluated using an eye-tracking disengagement task and an emotion regulation paradigm, respectively. MCAT, either alone or combined with tDCS, resulted in improved attention regulation. Furthermore, the group receiving combined MCAT and tDCS also showed some evidence of increased reappraisal ability and reduced rumination. MCAT in combination with left DLPFC neuromodulation has potential to maximize transfer to emotion regulation capacities and to promote resilience.

Original languageEnglish
Article number110177
Number of pages9
JournalProgress in Neuro-Psychopharmacology & Biological Psychiatry
Volume108
Early online date13 Nov 2020
DOIs
Publication statusPublished - Jun 2021

Bibliographical note

Copyright © 2020 Elsevier Inc. All rights reserved.

Keywords

  • DLPFC
  • Emotion regulation
  • Gaze-contingent attention training
  • Neurostimulation
  • Resilience

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