Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Daniel Chubb; Niels Weinhold; Peter Broderick; Bowang Chen; David C Johnson; Asta Försti; Jayaram Vijayakrishnan; Gabriele Migliorini; Sara E Dobbins; Amy Holroyd; Dirk Hose; Brian A Walker; Faith E Davies; Walter A Gregory; Graham H Jackson; Julie A Irving; Guy Pratt; Chris Fegan; James Al Fenton; Kai Neben; Per Hoffmann; Markus M Nöthen; Thomas W Mühleisen; Lewin Eisele; Fiona M Ross; Christian Straka; Hermann Einsele; Christian Langer; Elisabeth Dörner; James M Allan; Anna Jauch; Gareth J Morgan; Kari Hemminki; Richard S Houlston; Hartmut Goldschmidt

doi:10.1038/ng.2733

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Daniel Chubb, Niels Weinhold, Peter Broderick, Bowang Chen, David C Johnson, Asta Försti, Jayaram Vijayakrishnan, Gabriele Migliorini, Sara E Dobbins, Amy Holroyd, Dirk Hose, Brian A Walker, Faith E Davies, Walter A Gregory, Graham H Jackson, Julie A Irving, Guy Pratt, Chris Fegan, James Al Fenton, Kai NebenPer Hoffmann, Markus M Nöthen, Thomas W Mühleisen, Lewin Eisele, Fiona M Ross, Christian Straka, Hermann Einsele, Christian Langer, Elisabeth Dörner, James M Allan, Anna Jauch, Gareth J Morgan, Kari Hemminki, Richard S Houlston, Hartmut Goldschmidt

Basic (bio-) Medical Sciences

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Abstract

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

Original language	English
Pages (from-to)	1221-1225
Number of pages	5
Journal	Nature Genetics
Volume	45
Issue number	10
DOIs	https://doi.org/10.1038/ng.2733
Publication status	Published - 2013

Keywords

Case-Control Studies
Chromosome Aberrations
Chromosomes, Human
Genetic Predisposition to Disease
Humans
Multiple Myeloma/genetics

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10.1038/ng.2733

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Chubb, D., Weinhold, N., Broderick, P., Chen, B., Johnson, D. C., Försti, A., Vijayakrishnan, J., Migliorini, G., Dobbins, S. E., Holroyd, A., Hose, D., Walker, B. A., Davies, F. E., Gregory, W. A., Jackson, G. H., Irving, J. A., Pratt, G., Fegan, C., Fenton, J. A., ... Goldschmidt, H. (2013). Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nature Genetics, 45(10), 1221-1225. https://doi.org/10.1038/ng.2733

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title = "Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk",

abstract = "To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition. ",

keywords = "Case-Control Studies, Chromosome Aberrations, Chromosomes, Human, Genetic Predisposition to Disease, Humans, Multiple Myeloma/genetics",

author = "Daniel Chubb and Niels Weinhold and Peter Broderick and Bowang Chen and Johnson, {David C} and Asta F{\"o}rsti and Jayaram Vijayakrishnan and Gabriele Migliorini and Dobbins, {Sara E} and Amy Holroyd and Dirk Hose and Walker, {Brian A} and Davies, {Faith E} and Gregory, {Walter A} and Jackson, {Graham H} and Irving, {Julie A} and Guy Pratt and Chris Fegan and Fenton, {James Al} and Kai Neben and Per Hoffmann and N{\"o}then, {Markus M} and M{\"u}hleisen, {Thomas W} and Lewin Eisele and Ross, {Fiona M} and Christian Straka and Hermann Einsele and Christian Langer and Elisabeth D{\"o}rner and Allan, {James M} and Anna Jauch and Morgan, {Gareth J} and Kari Hemminki and Houlston, {Richard S} and Hartmut Goldschmidt",

year = "2013",

doi = "10.1038/ng.2733",

language = "English",

volume = "45",

pages = "1221--1225",

journal = "Nature Genetics",

issn = "1061-4036",

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Chubb, D, Weinhold, N, Broderick, P, Chen, B, Johnson, DC, Försti, A, Vijayakrishnan, J, Migliorini, G, Dobbins, SE, Holroyd, A, Hose, D, Walker, BA, Davies, FE, Gregory, WA, Jackson, GH, Irving, JA, Pratt, G, Fegan, C, Fenton, JA, Neben, K, Hoffmann, P, Nöthen, MM, Mühleisen, TW, Eisele, L, Ross, FM, Straka, C, Einsele, H, Langer, C, Dörner, E, Allan, JM, Jauch, A, Morgan, GJ, Hemminki, K, Houlston, RS & Goldschmidt, H 2013, 'Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk', Nature Genetics, vol. 45, no. 10, pp. 1221-1225. https://doi.org/10.1038/ng.2733

TY - JOUR

T1 - Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

AU - Chubb, Daniel

AU - Weinhold, Niels

AU - Broderick, Peter

AU - Chen, Bowang

AU - Johnson, David C

AU - Försti, Asta

AU - Vijayakrishnan, Jayaram

AU - Migliorini, Gabriele

AU - Dobbins, Sara E

AU - Holroyd, Amy

AU - Hose, Dirk

AU - Walker, Brian A

AU - Davies, Faith E

AU - Gregory, Walter A

AU - Jackson, Graham H

AU - Irving, Julie A

AU - Pratt, Guy

AU - Fegan, Chris

AU - Fenton, James Al

AU - Neben, Kai

AU - Hoffmann, Per

AU - Nöthen, Markus M

AU - Mühleisen, Thomas W

AU - Eisele, Lewin

AU - Ross, Fiona M

AU - Straka, Christian

AU - Einsele, Hermann

AU - Langer, Christian

AU - Dörner, Elisabeth

AU - Allan, James M

AU - Jauch, Anna

AU - Morgan, Gareth J

AU - Hemminki, Kari

AU - Houlston, Richard S

AU - Goldschmidt, Hartmut

PY - 2013

Y1 - 2013

N2 - To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

AB - To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

KW - Case-Control Studies

KW - Chromosome Aberrations

KW - Chromosomes, Human

KW - Genetic Predisposition to Disease

KW - Humans

KW - Multiple Myeloma/genetics

U2 - 10.1038/ng.2733

DO - 10.1038/ng.2733

M3 - Article

C2 - 23955597

SN - 1061-4036

VL - 45

SP - 1221

EP - 1225

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

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Keywords

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