Comparing the Separation Speed of Contemporary LC SFC, and GC

Sander Jespers; Ken Broeckhoven; Gert Desmet

Comparing the Separation Speed of Contemporary LC SFC, and GC

Sander Jespers, Ken Broeckhoven, Gert Desmet

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Some 50 years after Giddings's iconic comparison of the separation speed of gas chromatography (GC) and liquid chromatography (LC), the authors revisit this comparison using kinetic plots of the current state-of-the-art systems in LC, supercritical fluid chromatography (SFC), and GC. It is found that, despite the major progress LC has made in the past decade (sub-2-mu m particles, pressures up to 1500 bar, core-shell particles), a fully optimized ultrahigh-pressure liquid chromatography (UHPLC) separation is still at least one order of magnitude slower than capillary GC. The speed limits of packed bed SFC are situated in between.

Original language	English
Pages (from-to)	284-291
Number of pages	7
Journal	LC-GC Europe
Volume	30
Issue number	6
Publication status	Published - Jun 2017

Keywords

Supercritical-fluid chromatography
Core-shell particles
kinetic plot method
SUB-2 MU-M
superficially porous particles
tubular capillary columns
liquid-chromatography
gas-chromatography
high-pressures
Mobile-Phase

SRP6: Strategic Research Programme: Exploiting the Advantages of Order and Geometrical Structure for a Greener Chemistry
Desmet, G., Denayer, J., Denayer, J., Desmet, G. & Denayer, J.
1/11/12 → 31/10/22
Project: Fundamental

Cite this

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title = "Comparing the Separation Speed of Contemporary LC SFC, and GC",

abstract = "Some 50 years after Giddings's iconic comparison of the separation speed of gas chromatography (GC) and liquid chromatography (LC), the authors revisit this comparison using kinetic plots of the current state-of-the-art systems in LC, supercritical fluid chromatography (SFC), and GC. It is found that, despite the major progress LC has made in the past decade (sub-2-mu m particles, pressures up to 1500 bar, core-shell particles), a fully optimized ultrahigh-pressure liquid chromatography (UHPLC) separation is still at least one order of magnitude slower than capillary GC. The speed limits of packed bed SFC are situated in between.",

keywords = "Supercritical-fluid chromatography, Core-shell particles, kinetic plot method, SUB-2 MU-M, superficially porous particles, tubular capillary columns, liquid-chromatography, gas-chromatography, high-pressures, Mobile-Phase",

author = "Sander Jespers and Ken Broeckhoven and Gert Desmet",

year = "2017",

month = jun,

language = "English",

volume = "30",

pages = "284--291",

journal = "LC-GC Europe",

issn = "1471-6577",

publisher = "Advanstar Communications",

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T1 - Comparing the Separation Speed of Contemporary LC SFC, and GC

AU - Jespers, Sander

AU - Broeckhoven, Ken

AU - Desmet, Gert

PY - 2017/6

Y1 - 2017/6

N2 - Some 50 years after Giddings's iconic comparison of the separation speed of gas chromatography (GC) and liquid chromatography (LC), the authors revisit this comparison using kinetic plots of the current state-of-the-art systems in LC, supercritical fluid chromatography (SFC), and GC. It is found that, despite the major progress LC has made in the past decade (sub-2-mu m particles, pressures up to 1500 bar, core-shell particles), a fully optimized ultrahigh-pressure liquid chromatography (UHPLC) separation is still at least one order of magnitude slower than capillary GC. The speed limits of packed bed SFC are situated in between.

AB - Some 50 years after Giddings's iconic comparison of the separation speed of gas chromatography (GC) and liquid chromatography (LC), the authors revisit this comparison using kinetic plots of the current state-of-the-art systems in LC, supercritical fluid chromatography (SFC), and GC. It is found that, despite the major progress LC has made in the past decade (sub-2-mu m particles, pressures up to 1500 bar, core-shell particles), a fully optimized ultrahigh-pressure liquid chromatography (UHPLC) separation is still at least one order of magnitude slower than capillary GC. The speed limits of packed bed SFC are situated in between.

KW - Supercritical-fluid chromatography

KW - Core-shell particles

KW - kinetic plot method

KW - SUB-2 MU-M

KW - superficially porous particles

KW - tubular capillary columns

KW - liquid-chromatography

KW - gas-chromatography

KW - high-pressures

KW - Mobile-Phase

M3 - Article

VL - 30

SP - 284

EP - 291

JO - LC-GC Europe

JF - LC-GC Europe

SN - 1471-6577

IS - 6

ER -

Comparing the Separation Speed of Contemporary LC SFC, and GC

Abstract

Keywords

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Projects

SRP6: Strategic Research Programme: Exploiting the Advantages of Order and Geometrical Structure for a Greener Chemistry

Cite this