Computed tomographic angiography in coronary artery disease

Patrick W Serruys; Nozomi Kotoku; Bjarne L Nørgaard; Scot Garg; Koen Nieman; Marc R Dweck; Jeroen J Bax; Juhani Knuuti; Jagat Narula; Divaka Perera; Charles A Taylor; Jonathon A Leipsic; Edward D Nicol; Nicolo Piazza; Carl J Schultz; Kakuya Kitagawa; Bernard De Bruyne; Carlos Collet; Kaoru Tanaka; Saima Mushtaq; Marta Belmonte; Darius Dudek; Adriana Zlahoda-Huzior; Shengxian Tu; William Wijns; Faisal Sharif; Matthew J Budoff; Johan de Mey; Daniele Andreini; Yoshinobu Onuma

doi:10.4244/EIJ-D-22-00776

Computed tomographic angiography in coronary artery disease

Patrick W Serruys, Nozomi Kotoku, Bjarne L Nørgaard, Scot Garg, Koen Nieman, Marc R Dweck, Jeroen J Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A Taylor, Jonathon A Leipsic, Edward D Nicol, Nicolo Piazza, Carl J Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima MushtaqMarta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive coronary arteries are also expected to be assessed by non-invasive imaging, including CCTA. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining the disease complexity, vessel size, lesion length and tissue composition of the atherosclerotic plaque, as well as the best fluoroscopic viewing angle; it may also help in selecting adjunctive percutaneous devices (e.g., rotational atherectomy) and in determining the best landing zone for stents or bypass grafts.

Original language	English
Pages (from-to)	e1307-e1327
Number of pages	20
Journal	EuroIntervention
Volume	18
Issue number	16
DOIs	https://doi.org/10.4244/EIJ-D-22-00776
Publication status	Published - 3 Apr 2023

Bibliographical note

Funding Information:
C. Collet has received research grants from GE Healthcare, Siemens, Coroventis Research, Medis Medical Imaging, Pie Medical Imaging, CathWorks, Boston Scientific, HeartFlow, and Abbott Vascular; and consultancy fees from HeartFlow, CryoTherapeutics, and Abbott Vascular. A. Zlahoda-Huzior is a former employee of MedApp. S. Tu reports research grants and consultancy fees from Pulse Medical outside of this submitted work. W. Wijns is supported by the Science Foundation Ireland Research Professorship Award (15/RP/2765). M.J. Budoff has received grant support from General Electric and the National Institutes of Health. The other authors have no conflicts of interest to declare.

Publisher Copyright:
© 2023 OSA - The Optical Society. All rights reserved.

Keywords

fractional flow reserve
MSCT
Non-invasive imaging

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Serruys, P. W., Kotoku, N., Nørgaard, B. L., Garg, S., Nieman, K., Dweck, M. R., Bax, J. J., Knuuti, J., Narula, J., Perera, D., Taylor, C. A., Leipsic, J. A., Nicol, E. D., Piazza, N., Schultz, C. J., Kitagawa, K., Bruyne, B. D., Collet, C., Tanaka, K., ... Onuma, Y. (2023). Computed tomographic angiography in coronary artery disease. EuroIntervention, 18(16), e1307-e1327. https://doi.org/10.4244/EIJ-D-22-00776

Serruys, Patrick W ; Kotoku, Nozomi ; Nørgaard, Bjarne L ; Garg, Scot ; Nieman, Koen ; Dweck, Marc R ; Bax, Jeroen J ; Knuuti, Juhani ; Narula, Jagat ; Perera, Divaka ; Taylor, Charles A ; Leipsic, Jonathon A ; Nicol, Edward D ; Piazza, Nicolo ; Schultz, Carl J ; Kitagawa, Kakuya ; Bruyne, Bernard De ; Collet, Carlos ; Tanaka, Kaoru ; Mushtaq, Saima ; Belmonte, Marta ; Dudek, Darius ; Zlahoda-Huzior, Adriana ; Tu, Shengxian ; Wijns, William ; Sharif, Faisal ; Budoff, Matthew J ; Mey, Johan de ; Andreini, Daniele ; Onuma, Yoshinobu. / Computed tomographic angiography in coronary artery disease. In: EuroIntervention. 2023 ; Vol. 18, No. 16. pp. e1307-e1327.

@article{fbe7b186d46b47cd971319d63a2104b5,

title = "Computed tomographic angiography in coronary artery disease",

abstract = "Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive coronary arteries are also expected to be assessed by non-invasive imaging, including CCTA. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining the disease complexity, vessel size, lesion length and tissue composition of the atherosclerotic plaque, as well as the best fluoroscopic viewing angle; it may also help in selecting adjunctive percutaneous devices (e.g., rotational atherectomy) and in determining the best landing zone for stents or bypass grafts.",

keywords = "fractional flow reserve, MSCT, Non-invasive imaging",

author = "Serruys, {Patrick W} and Nozomi Kotoku and N{\o}rgaard, {Bjarne L} and Scot Garg and Koen Nieman and Dweck, {Marc R} and Bax, {Jeroen J} and Juhani Knuuti and Jagat Narula and Divaka Perera and Taylor, {Charles A} and Leipsic, {Jonathon A} and Nicol, {Edward D} and Nicolo Piazza and Schultz, {Carl J} and Kakuya Kitagawa and Bruyne, {Bernard De} and Carlos Collet and Kaoru Tanaka and Saima Mushtaq and Marta Belmonte and Darius Dudek and Adriana Zlahoda-Huzior and Shengxian Tu and William Wijns and Faisal Sharif and Budoff, {Matthew J} and Mey, {Johan de} and Daniele Andreini and Yoshinobu Onuma",

note = "Funding Information: C. Collet has received research grants from GE Healthcare, Siemens, Coroventis Research, Medis Medical Imaging, Pie Medical Imaging, CathWorks, Boston Scientific, HeartFlow, and Abbott Vascular; and consultancy fees from HeartFlow, CryoTherapeutics, and Abbott Vascular. A. Zlahoda-Huzior is a former employee of MedApp. S. Tu reports research grants and consultancy fees from Pulse Medical outside of this submitted work. W. Wijns is supported by the Science Foundation Ireland Research Professorship Award (15/RP/2765). M.J. Budoff has received grant support from General Electric and the National Institutes of Health. The other authors have no conflicts of interest to declare. Publisher Copyright: {\textcopyright} 2023 OSA - The Optical Society. All rights reserved.",

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doi = "10.4244/EIJ-D-22-00776",

language = "English",

volume = "18",

pages = "e1307--e1327",

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Serruys, PW, Kotoku, N, Nørgaard, BL, Garg, S, Nieman, K, Dweck, MR, Bax, JJ, Knuuti, J, Narula, J, Perera, D, Taylor, CA, Leipsic, JA, Nicol, ED, Piazza, N, Schultz, CJ, Kitagawa, K, Bruyne, BD, Collet, C, Tanaka, K, Mushtaq, S, Belmonte, M, Dudek, D, Zlahoda-Huzior, A, Tu, S, Wijns, W, Sharif, F, Budoff, MJ, Mey, JD, Andreini, D & Onuma, Y 2023, 'Computed tomographic angiography in coronary artery disease', EuroIntervention, vol. 18, no. 16, pp. e1307-e1327. https://doi.org/10.4244/EIJ-D-22-00776

Computed tomographic angiography in coronary artery disease. / Serruys, Patrick W; Kotoku, Nozomi; Nørgaard, Bjarne L; Garg, Scot; Nieman, Koen; Dweck, Marc R; Bax, Jeroen J; Knuuti, Juhani; Narula, Jagat; Perera, Divaka; Taylor, Charles A; Leipsic, Jonathon A; Nicol, Edward D; Piazza, Nicolo; Schultz, Carl J; Kitagawa, Kakuya; Bruyne, Bernard De; Collet, Carlos; Tanaka, Kaoru; Mushtaq, Saima; Belmonte, Marta; Dudek, Darius; Zlahoda-Huzior, Adriana; Tu, Shengxian; Wijns, William; Sharif, Faisal; Budoff, Matthew J; Mey, Johan de; Andreini, Daniele; Onuma, Yoshinobu.

In: EuroIntervention, Vol. 18, No. 16, 03.04.2023, p. e1307-e1327.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Computed tomographic angiography in coronary artery disease

AU - Serruys, Patrick W

AU - Kotoku, Nozomi

AU - Nørgaard, Bjarne L

AU - Garg, Scot

AU - Nieman, Koen

AU - Dweck, Marc R

AU - Bax, Jeroen J

AU - Knuuti, Juhani

AU - Narula, Jagat

AU - Perera, Divaka

AU - Taylor, Charles A

AU - Leipsic, Jonathon A

AU - Nicol, Edward D

AU - Piazza, Nicolo

AU - Schultz, Carl J

AU - Kitagawa, Kakuya

AU - Bruyne, Bernard De

AU - Collet, Carlos

AU - Tanaka, Kaoru

AU - Mushtaq, Saima

AU - Belmonte, Marta

AU - Dudek, Darius

AU - Zlahoda-Huzior, Adriana

AU - Tu, Shengxian

AU - Wijns, William

AU - Sharif, Faisal

AU - Budoff, Matthew J

AU - Mey, Johan de

AU - Andreini, Daniele

AU - Onuma, Yoshinobu

N1 - Funding Information: C. Collet has received research grants from GE Healthcare, Siemens, Coroventis Research, Medis Medical Imaging, Pie Medical Imaging, CathWorks, Boston Scientific, HeartFlow, and Abbott Vascular; and consultancy fees from HeartFlow, CryoTherapeutics, and Abbott Vascular. A. Zlahoda-Huzior is a former employee of MedApp. S. Tu reports research grants and consultancy fees from Pulse Medical outside of this submitted work. W. Wijns is supported by the Science Foundation Ireland Research Professorship Award (15/RP/2765). M.J. Budoff has received grant support from General Electric and the National Institutes of Health. The other authors have no conflicts of interest to declare. Publisher Copyright: © 2023 OSA - The Optical Society. All rights reserved.

PY - 2023/4/3

Y1 - 2023/4/3

N2 - Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive coronary arteries are also expected to be assessed by non-invasive imaging, including CCTA. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining the disease complexity, vessel size, lesion length and tissue composition of the atherosclerotic plaque, as well as the best fluoroscopic viewing angle; it may also help in selecting adjunctive percutaneous devices (e.g., rotational atherectomy) and in determining the best landing zone for stents or bypass grafts.

AB - Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive coronary arteries are also expected to be assessed by non-invasive imaging, including CCTA. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining the disease complexity, vessel size, lesion length and tissue composition of the atherosclerotic plaque, as well as the best fluoroscopic viewing angle; it may also help in selecting adjunctive percutaneous devices (e.g., rotational atherectomy) and in determining the best landing zone for stents or bypass grafts.

KW - fractional flow reserve

KW - MSCT

KW - Non-invasive imaging

U2 - 10.4244/EIJ-D-22-00776

DO - 10.4244/EIJ-D-22-00776

M3 - Article

C2 - 37025086

VL - 18

SP - e1307-e1327

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 16

ER -

Computed tomographic angiography in coronary artery disease

Abstract

Bibliographical note

Keywords

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