Con: Dialy- and continuous renal replacement (CRRT) trauma during renal replacement therapy: still under-recognized but on the way to better diagnostic understanding and prevention.

Patrick Honore, Rita Jacobs, Olivier Joannes-Boyau, Elisabeth De Waele, Viola Van Gorp, Willem Boer, Herbert Spapen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dialy- and continuous renal replacement (CRRT) trauma are still un(der)recognized conditions that may be encountered during blood purification therapy. This particular form of trauma requires timely identification, a better understanding of pathophysiology and a definition of at-risk groups to prevent or correct any associated unwarranted effects. Among others, progress in the knowledge of antimicrobial pharmacokinetic/pharmacodynamic (PK/PD) behaviour during CRRT to obtain more efficient antimicrobial therapy with less side-effects is one key example of limiting CRRT trauma. Optimal anticipation and prevention of CRRT trauma will preserve the safe use of CRRT in haemodynamically unstable critically ill patients with acute kidney injury (AKI), especially in septic patients who are at the greatest risk.
Original languageEnglish
Pages (from-to)2723-2728
Number of pages6
JournalNephrology Dialysis Transplantation
Volume28
Issue numberNovember
DOIs
Publication statusPublished - 2014

Keywords

  • AKI
  • CRRT-trauma
  • Antibiotics
  • dialy-trauma

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