Concise Review - Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration

Naomi Van Gassen, Willem Staels, Eva Van Overmeire, Sofie De Groef, Mozhdeh Sojoodi, Yves Heremans, Gunter Leuckx, Mark Van de Casteele, Jo A Van Ginderachter, Henry Heimberg, Nico De Leu

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Macrophages are classically considered detrimental for pancreatic β-cell survival and function, thereby contributing to β-cell failure in both type 1 (T1D) and 2 (T2D) diabetes mellitus. In addition, adipose tissue macrophages negatively influence peripheral insulin signaling and promote obesity-induced insulin resistance in T2D. In contrast, recent data unexpectedly uncovered that macrophages are not only able to protect β cells during pancreatitis but also to orchestrate β-cell proliferation and regeneration after β-cell injury. Moreover, by altering their activation state, macrophages are able to improve insulin resistance in murine models of T2D. This review will elaborate on current insights in macrophage heterogeneity and on the evolving role of pancreas macrophages during organogenesis, tissue injury, and repair. Additional identification of macrophage subtypes and of their secreted factors might ultimately translate into novel therapeutic strategies for both T1D and T2D.

Original languageEnglish
Pages (from-to)555-563
Number of pages12
JournalStem Cells Translational Medicine
Volume4
Issue number6
DOIs
Publication statusPublished - 6 Apr 2015

Bibliographical note

©AlphaMed Press.

Fingerprint

Dive into the research topics of 'Concise Review - Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration'. Together they form a unique fingerprint.

Cite this