Projects per year
Abstract
Gap junctions, which mediate intercellular communication, are key players in digestive homeostasis. They are also frequently involved in gastrointestinal and liver pathology. This equally holds true for connexin (Cx) hemichannels, the structural precursors of gap junctions, and pannexin (Panx) channels, Cx-like proteins assembled in a hemichannel configuration. Both Cx hemichannels and Panx channels facilitate extracellular communication and drive a number of deteriorative processes, such as cell death and inflammation. Cxs, Panxs, and their channels underlie a wide spectrum of gastrointestinal and liver diseases, including gastritis and peptic ulcer disease, inflammatory intestinal conditions, acute liver failure, cholestasis, hepatitis and steatosis, liver fibrosis and cirrhosis, infectious gastrointestinal pathologies, and gastrointestinal and liver cancer. This could open promising perspectives for the characterization of new targets and biomarkers for therapeutic and diagnostic clinical purposes in the area of gastroenterology and hepatology.
Original language | English |
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Pages (from-to) | 332-343 |
Journal | Translational Research |
Volume | 166 |
Issue number | 4 |
Early online date | 16 May 2015 |
DOIs | |
Publication status | Published - 1 Oct 2015 |
Keywords
- stomach
- Intestine
- liver
- cellular communication
- disease
Fingerprint
Dive into the research topics of 'Connexin and pannexin signaling in gastrointestinal and liver disease'. Together they form a unique fingerprint.-
OZR2651: International Joint Research Group - Liver Connexin and Pannexin Research Group (LCPR)
Vinken, M., Rogiers, V., Cogliati, B. & Dagli, M. L.
1/08/14 → 1/07/26
Project: Fundamental
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OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes
10/06/15 → 31/07/17
Project: Fundamental
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Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity
Maes, M., McGill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Weemhoff, J. L., Tiburcio, T., Veloso Alves Pereira, I., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J. A., Penuela, S., Jaeschke, H., Cogliati, B. & Vinken, M., 1 May 2017, In: Archives of Toxicology. 91, 5, p. 2245-2261 17 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Connexins and pannexins in liver damage
Crespo Yanguas, S., Willebrords, J., Maes, M., da Silva, T. C., Alves Pereira, I. V., Cogliati, B., Zaidan Dagli, M. L. & Vinken, M., 18 Feb 2016, In: EXCLI Journal. 15, p. 177-186 10 p.Research output: Contribution to journal › Article › peer-review
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Involvement of connexin43 in acetaminophen-induced liver injury
Maes, M., Mcgill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Monteiro de Araújo, C. M., Tiburcio, T., Alves Pereira, I. V., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J., Zaidan Dagli, M. L., Jaeschke, H., Cogliati, B. & Vinken, M., 1 Jun 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 6, p. 1111-1121 11 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus)
Activities
- 1 Talk or presentation at a workshop/seminar
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The role of connexins, pannexins and their channels in liver fibrosis
Sara Crespo Yanguas (Speaker)
28 Nov 2018Activity: Talk or presentation › Talk or presentation at a workshop/seminar