Connexins and pannexins in liver damage

Sara Crespo Yanguas, Joost Willebrords, Michaël Maes, Tereza Cristina da Silva, Isabel Veloso Alves Pereira, Bruno Cogliati, Maria Lucia Zaidan Dagli, Mathieu Vinken

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.
Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalEXCLI Journal
Volume15
Publication statusPublished - 18 Feb 2016

Keywords

  • Connexin
  • Pannexin
  • liver damage

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