Connexins and pannexins in liver damage

Sara Crespo Yanguas; Joost Willebrords; Michaël Maes; Tereza Cristina da Silva; Isabel Veloso Alves Pereira; Bruno Cogliati; Maria Lucia Zaidan Dagli; Mathieu Vinken

Connexins and pannexins in liver damage

Sara Crespo Yanguas, Joost Willebrords, Michaël Maes, Tereza Cristina da Silva, Isabel Veloso Alves Pereira, Bruno Cogliati, Maria Lucia Zaidan Dagli, Mathieu Vinken

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.

Original language	English
Pages (from-to)	177-186
Number of pages	10
Journal	EXCLI Journal
Volume	15
Publication status	Published - 18 Feb 2016

Keywords

Connexin
Pannexin
liver damage

Handle.net

Persistent link

1 Active
8 Finished

OZR2651: International Joint Research Group - Liver Connexin and Pannexin Research Group (LCPR)
Vinken, M. (Administrative Promotor), Rogiers, V. (Co-Promotor), Cogliati, B. (Co-Promotor) & Dagli, M. L. (Co-Promotor)
1/08/14 → 1/07/26
Project: Fundamental
OZR2814: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject - Bench fee voor Joint PhD, VUB-Universidade de Sao Paulo, Sara Crespo Yanguas
Vinken, M. (Administrative Promotor)
10/06/15 → 31/07/17
Project: Fundamental
OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes
Vinken, M. (Administrative Promotor)
10/06/15 → 31/07/17
Project: Fundamental

Connexin32: a mediator of acetaminophen-induced liver injury?
Maes, M., Mcgill, M. R., da Silva, T. C., Lebofsky, M., Monteiro de Araújo, C. M., Tiburcio, T., Alves Pereira, I. V., Willebrords, J., Crespo Yanguas, S., Farhood, A., Zaidan Dagli, M. L., Jaeschke, H., Cogliati, B. & Vinken, M., 1 May 2016, In: Toxicology Mechanism and Methods. 26, 2, p. 88-96 9 p.
Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)
Connexins, pannexins and their channels in fibroproliferative diseases
Cogliati, B., Mennecier, G., Willebrords, J., da Silva, T. C., Maes, M., Alves Pereira, I. V., Crespo Yanguas, S., Hernandez-Blazquez, F., Zaidan Dagli, M. L. & Vinken, M., 23 May 2016, In: Journal of Membrane Biology. 249, 3, p. 199-213
Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus)
Involvement of connexin43 in acetaminophen-induced liver injury
Maes, M., Mcgill, M. R., da Silva, T. C., Abels, C., Lebofsky, M., Monteiro de Araújo, C. M., Tiburcio, T., Alves Pereira, I. V., Willebrords, J., Crespo Yanguas, S., Farhood, A., Beschin, A., Van Ginderachter, J., Zaidan Dagli, M. L., Jaeschke, H., Cogliati, B. & Vinken, M., 1 Jun 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 6, p. 1111-1121 11 p.
Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus)

The role of connexins, pannexins and their channels in liver fibrosis
Crespo Yanguas, S. (Speaker)
28 Nov 2018
Activity: Talk or presentation › Talk or presentation at a workshop/seminar

Cite this

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title = "Connexins and pannexins in liver damage",

abstract = "Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.",

keywords = "Connexin, Pannexin, liver damage",

author = "{Crespo Yanguas}, Sara and Joost Willebrords and Micha{\"e}l Maes and {da Silva}, {Tereza Cristina} and {Alves Pereira}, {Isabel Veloso} and Bruno Cogliati and {Zaidan Dagli}, {Maria Lucia} and Mathieu Vinken",

year = "2016",

month = feb,

day = "18",

language = "English",

volume = "15",

pages = "177--186",

journal = "EXCLI Journal",

issn = "1611-2156",

publisher = "University of Mainz",

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TY - JOUR

T1 - Connexins and pannexins in liver damage

AU - Crespo Yanguas, Sara

AU - Willebrords, Joost

AU - Maes, Michaël

AU - da Silva, Tereza Cristina

AU - Alves Pereira, Isabel Veloso

AU - Cogliati, Bruno

AU - Zaidan Dagli, Maria Lucia

AU - Vinken, Mathieu

PY - 2016/2/18

Y1 - 2016/2/18

N2 - Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.

AB - Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets.

KW - Connexin

KW - Pannexin

KW - liver damage

M3 - Article

SN - 1611-2156

VL - 15

SP - 177

EP - 186

JO - EXCLI Journal

JF - EXCLI Journal

ER -

Connexins and pannexins in liver damage

Abstract

Keywords

Handle.net

Fingerprint

Projects

OZR2651: International Joint Research Group - Liver Connexin and Pannexin Research Group (LCPR)

OZR2814: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject - Bench fee voor Joint PhD, VUB-Universidade de Sao Paulo, Sara Crespo Yanguas

OZR2813: Bilaterale samenwerking ikv gemeenschappelijke doctoraatsproject: Bench Fee voor Joint PhD VUB-Universidade de Sao Paulo, Michael Maes

Research output

Connexin32: a mediator of acetaminophen-induced liver injury?

Connexins, pannexins and their channels in fibroproliferative diseases

Involvement of connexin43 in acetaminophen-induced liver injury

Activities

The role of connexins, pannexins and their channels in liver fibrosis

Cite this