Corneal endothelial wound healing: understanding the regenerative capacity of the innermost layer of the cornea

HENDRIK Vercammen, ALINA MIRON, SILKE OELLERICH, GERRIT R.J. MELLES, SORCHA Ní Dhubhghaill, CARINA KOPPEN, B. E.R.T. Van Den Bogerd

Research output: Contribution to journalScientific reviewpeer-review

7 Citations (Scopus)

Abstract

Currently, there are very few well-established treatments to stimulate corneal endothelial cell regeneration in vivo as a cure for corneal endothelial dysfunctions. The most frequently performed intervention for a damaged or dysfunctional corneal endothelium nowadays is corneal endothelial keratoplasty, also known as lamellar corneal transplantation surgery. Newer medical therapies are emerging and are targeting the regeneration of the corneal endothelium, helping the patients regain their vision without the need for donor tissue. Alternatives to donor tissues are needed as the aging population requiring transplants, has further exacerbated the pressure on the corneal eye banking system. Significant ongoing research efforts in the field of corneal regenerative medicine have been made to elucidate the underlying pathways and effector proteins involved in corneal endothelial regeneration. However, the literature offers little guidance and selective attention to the question of how to fully exploit these pathways. The purpose of this paper is to provide an overview of wound healing characteristics from a biochemical level in the lab to the regenerative features seen in the clinic. Studying the pathways involved in corneal wound healing together with their key effector proteins, can help explain the effect on the proliferation and migration capacity of the corneal endothelial cells.

Original languageEnglish
Article number16
Pages (from-to)111-127
Number of pages17
JournalTranslational research : the journal of laboratory and clinical medicine
Volume248
Issue numbern/a
DOIs
Publication statusPublished - Oct 2022

Bibliographical note

Funding Information:
Funding: This study was supported by the Funds for Scientific Research Flanders (FWO) by their funding grants for the project of BVdB ( 3G059419N ) and the mandate that HV received ( 1S09722N ).

Publisher Copyright:
© 2022 The Authors

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