1 Citation (Scopus)


OBJECTIVES: Spinal cord stimulation (SCS) is considered an effective pain-relieving treatment for patients with Failed Back Surgery Syndrome (FBSS). Despite the clinical effectiveness, it is unknown whether the altered functional connectivity in such patients, as compared to healthy persons, can be influenced by SCS. Therefore, the goal of this study is to evaluate whether brain connectivity assessed by EEG differs between baseline and SCS in patients with FBSS.

MATERIALS AND METHODS: Eight patients with FBSS underwent a resting-state EEG protocol before SCS, 1.5 months and 2.5 months after receiving SCS. At each frequency band, power spectrums were compared for no SCS, conventional (CON) SCS and High Dose (HD) SCS. Functional connectivity, with the aid of eConnectome was also calculated.

RESULTS: Significant differences in the average power density spectrum over the whole scalp were observed between no SCS, CON SCS and HD SCS in delta, theta and beta frequency bands (p < 0.01). The average power spectrum for CON SCS was significantly lower than the average power spectrum for HD SCS. Marked increases in strength of the information flow between electrode pair FC3-TP9 in the beta frequency band (p = 0.006) were found in favor of HD SCS.

CONCLUSIONS: The differences in power spectrum and connectivity between the three conditions lead to the hypothesis that HD SCS differs from CON SCS on average power spectrum, suggesting that HD SCS may have a higher contribution on the excitatory bottom-up pathway.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
Issue number1
Early online date10 Jun 2019
Publication statusPublished - Jan 2020

Bibliographical note

© 2019 International Neuromodulation Society.


  • Electroencephalography
  • Failed Back Surgery Syndrome
  • High Dose SCS
  • Spinal Cord Stimulation
  • supraspinal mechanisms

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