Cyclisation To Form Small, Medium and Large Rings by Use of Catalysed and Uncatalysed Azide–Alkyne Cycloadditions (AACs). IF 2.882

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19 Citations (Scopus)

Abstract

This microreview briefly summarises recent developments in cyclisation to afford small, medium and large rings (five to 30 members) by way of both catalysed and uncatalysed azide–alkyne cycloaddition (AAC). The standard AAC reactions – intramolecular Huisgen, CuAAC and RuAAC – are presented, as well as some of their contemporary variations. In addition, we present useful strategies for overcoming common problems encountered in these reactions.

Original languageEnglish
Pages (from-to)4678-4694
Number of pages17
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number32
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Azides
  • Click chemistry
  • Cyclization
  • Dimerization
  • Macrocycles

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