Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model

Eva Gijbels, Lindsey Devisscher, Mathieu Vinken

Research output: Contribution to journalArticle

Abstract

The transcriptomic dataset (whole genome microarray Affymetrix Human U133 plus 2.0 and Affymetrix Mouse Genome 430 2.0) presented in this paper describes the differential gene expression profile of a human in vitro model of drug-induced cholestasis and a well-known mouse in vivo model of cholestasis. The in vitro model consists of human hepatoma HepaRG cells in monolayer configuration exposed to 3 different cholestatic drugs with or without bile acids. For in vivo modelling of cholestasis, mice were subjected to bile duct ligation surgery. Consecutive normalization, summarization and background adjustments have been made by means of Robust Multichip Average Express software.

Original languageEnglish
Article number106156
JournalData in Brief
Volume32
DOIs
Publication statusPublished - Oct 2020

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