De novo KCNQ2 mutations in patients with benign neonatal seizures.

Lieve Claes, Berten Ceulemans, D. Audenaert, Liesbet Deprez, Anna Jansen, D. Hasaerts, S. Weckx, K.g. Claeys, Jurgen Del-Favero, Christine Van Broeckhoven, P. De Jonghe

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Benign familial neonatal convulsions (BFNC) are characterized by unprovoked seizures during the first weeks of life with spontaneous remission after a few months. Mutations have been identified in the voltage-gated potassium ion channels KCNQ2 and KCNQ3. The authors performed a mutation analysis of KCNQ2 and KCNQ3 in six patients of whom four had no family history of neonatal seizures. The authors identified three KCNQ2 mutations in four patients that all arose de novo.
Original languageEnglish
Pages (from-to)2155-2158
Number of pages4
JournalNeurology
Volume63
Publication statusPublished - 14 Dec 2004

Keywords

  • Neonatal seizures
  • KCNQ2

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