Dendritic Cells: The Tools for Cancer Treatment

Hanne Locy, Sarah Melhaoui, Sarah Maenhout, Kris Thielemans

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

During cancer immune editing, the immune system shapes tumor fate in three phases through the activation of innate and adaptive immune mechanisms. After the elimination and equilibrium phase, the escape phase represents the final phase in which immunologically sculpted tumors begin to grow progressively. In this chapter, we will discuss which efforts are made to restore the balance in favor of the immune system making use of dendritic cells (DCs). The first approach is adoptive cell transfer, in which autologous DCs are generated and activated ex vivo. Secondly, we will discuss attempts in which pro-inflammatory or pro-migratory factors are delivered to attract and activate DCs in situ. Both strategies have the general goal to activate and mature DCs able to induce a robust tumor-specific T cell response. In addition, this chapter will discuss the clinical impact of DC-based therapies in cancer treatment focusing on the safety, feasibility, immunological responses, and clinical outcome.
Original languageEnglish
Title of host publicationDendritic cells
EditorsSvetlana P. Chapoval
Chapter6
Pages101-128
Publication statusPublished - 7 Nov 2018

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