Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
Bibliographical note© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Bone Cements
- Bortezomib/administration & dosage
- Calcium Phosphates
- Cellulose/analogs & derivatives
- Delayed-Action Preparations
- Maltose/analogs & derivatives
- Mesenchymal Stem Cells/drug effects
- Osteogenesis/drug effects
- Polyethyleneimine/analogs & derivatives
- Proteasome Inhibitors/administration & dosage