DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing.

Robim Marcelino Rodrigues; S. Bremer-Hoffmann; Joery De Kock; Sylvia Escher; Jan Hengstler; Paul Jennings; Hector Keun; Jos Kleinjans; Kolde Raivo; Annette Kopp Schneider; Ringwald Annette; Vera Rogiers; Agapios Sachinidis; Sickmann Albert; Dimitry Spitkovsky; Tamara Vanhaecke; Mathieu Vinken; Bob Van De Water; Jurgen Hescheler

DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing.

Robim Marcelino Rodrigues, S. Bremer-Hoffmann, Joery De Kock, Sylvia Escher, Jan Hengstler, Paul Jennings, Hector Keun, Jos Kleinjans, Kolde Raivo, Annette Kopp Schneider, Ringwald Annette, Vera Rogiers, Agapios Sachinidis, Sickmann Albert, Dimitry Spitkovsky, Tamara Vanhaecke, Mathieu Vinken, Bob Van De Water, Jurgen Hescheler

Toxicology, Dermato-cosmetology and Pharmacognosy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

As one of the building blocks of the SEURAT-1 Research Initiative, the DETECTIVE project
focuses on a key element on which in vitro toxicity testing relies: the development of robust
and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be
used for safety assessments of chronically acting toxicants relevant for humans.

Original language	English
Title of host publication	Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing
Publisher	Mouzet Imprimerie
Pages	166-185
Number of pages	20
Volume	4
ISBN (Print)	978-2-9539634-3-4
Publication status	Published - 2014

Keywords

SEURAT-1
DETECTIVE

Access to Document

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Cite this

Marcelino Rodrigues, R., Bremer-Hoffmann, S., De Kock, J., Escher, S., Hengstler, J., Jennings, P., Keun, H., Kleinjans, J., Raivo, K., Kopp Schneider, A., Annette, R., Rogiers, V., Sachinidis, A., Albert, S., Spitkovsky, D., Vanhaecke, T., Vinken, M., Van De Water, B., & Hescheler, J. (2014). DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing. In Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing (Vol. 4, pp. 166-185). Mouzet Imprimerie. http://www.seurat-1.eu/pages/library/seurat-1-annual-report.php

Marcelino Rodrigues, Robim ; Bremer-Hoffmann, S. ; De Kock, Joery ; Escher, Sylvia ; Hengstler, Jan ; Jennings, Paul ; Keun, Hector ; Kleinjans, Jos ; Raivo, Kolde ; Kopp Schneider, Annette ; Annette, Ringwald ; Rogiers, Vera ; Sachinidis, Agapios ; Albert, Sickmann ; Spitkovsky, Dimitry ; Vanhaecke, Tamara ; Vinken, Mathieu ; Van De Water, Bob ; Hescheler, Jurgen. / DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing. Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing. Vol. 4 Mouzet Imprimerie, 2014. pp. 166-185

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title = "DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing.",

abstract = "As one of the building blocks of the SEURAT-1 Research Initiative, the DETECTIVE project focuses on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants relevant for humans.",

keywords = "SEURAT-1, DETECTIVE",

author = "{Marcelino Rodrigues}, Robim and S. Bremer-Hoffmann and {De Kock}, Joery and Sylvia Escher and Jan Hengstler and Paul Jennings and Hector Keun and Jos Kleinjans and Kolde Raivo and {Kopp Schneider}, Annette and Ringwald Annette and Vera Rogiers and Agapios Sachinidis and Sickmann Albert and Dimitry Spitkovsky and Tamara Vanhaecke and Mathieu Vinken and {Van De Water}, Bob and Jurgen Hescheler",

note = "COACH Ed., Paris, France",

year = "2014",

language = "English",

isbn = "978-2-9539634-3-4",

volume = "4",

pages = "166--185",

booktitle = "Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing",

publisher = "Mouzet Imprimerie",

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Marcelino Rodrigues, R, Bremer-Hoffmann, S, De Kock, J, Escher, S, Hengstler, J, Jennings, P, Keun, H, Kleinjans, J, Raivo, K, Kopp Schneider, A, Annette, R, Rogiers, V, Sachinidis, A, Albert, S, Spitkovsky, D, Vanhaecke, T , Vinken, M, Van De Water, B & Hescheler, J 2014, DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing. in Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing. vol. 4, Mouzet Imprimerie, pp. 166-185. <http://www.seurat-1.eu/pages/library/seurat-1-annual-report.php>

DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing. / Marcelino Rodrigues, Robim; Bremer-Hoffmann, S.; De Kock, Joery; Escher, Sylvia; Hengstler, Jan; Jennings, Paul; Keun, Hector; Kleinjans, Jos; Raivo, Kolde; Kopp Schneider, Annette; Annette, Ringwald; Rogiers, Vera; Sachinidis, Agapios; Albert, Sickmann; Spitkovsky, Dimitry; Vanhaecke, Tamara ; Vinken, Mathieu; Van De Water, Bob; Hescheler, Jurgen.

Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing. Vol. 4 Mouzet Imprimerie, 2014. p. 166-185.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing.

AU - Marcelino Rodrigues, Robim

AU - Bremer-Hoffmann, S.

AU - De Kock, Joery

AU - Escher, Sylvia

AU - Hengstler, Jan

AU - Jennings, Paul

AU - Keun, Hector

AU - Kleinjans, Jos

AU - Raivo, Kolde

AU - Kopp Schneider, Annette

AU - Annette, Ringwald

AU - Rogiers, Vera

AU - Sachinidis, Agapios

AU - Albert, Sickmann

AU - Spitkovsky, Dimitry

AU - Vanhaecke, Tamara

AU - Vinken, Mathieu

AU - Van De Water, Bob

AU - Hescheler, Jurgen

N1 - COACH Ed., Paris, France

PY - 2014

Y1 - 2014

N2 - As one of the building blocks of the SEURAT-1 Research Initiative, the DETECTIVE project focuses on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants relevant for humans.

AB - As one of the building blocks of the SEURAT-1 Research Initiative, the DETECTIVE project focuses on a key element on which in vitro toxicity testing relies: the development of robust and reliable, sensitive and specific in vitro biomarkers and surrogate endpoints that can be used for safety assessments of chronically acting toxicants relevant for humans.

KW - SEURAT-1

KW - DETECTIVE

M3 - Chapter

SN - 978-2-9539634-3-4

VL - 4

SP - 166

EP - 185

BT - Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing

PB - Mouzet Imprimerie

ER -

Marcelino Rodrigues R, Bremer-Hoffmann S, De Kock J, Escher S, Hengstler J, Jennings P et al. DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing. In Towards the Replacement of in vivo Repeated Dose Systemic Toxicity Testing. Vol. 4. Mouzet Imprimerie. 2014. p. 166-185

DETECTIVE: detection of endpoints and biomarkers for repeated dose toxicity testing using in vitro systems. Towards the replacement of in vivo repeated dose systemic toxicity testing.

Abstract

Keywords

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