Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review

eurUS.brain group

doi:10.1038/s41390-020-0777-x

Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review

eurUS.brain group

Research output: Contribution to journal › Scientific review › peer-review

33 Citations (Scopus)

132 Downloads (Pure)

Abstract

INTRODUCTION: Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.

METHODS: A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.

RESULTS: In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.

DISCUSSION: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.

Original language	English
Pages (from-to)	50-58
Number of pages	9
Journal	Pediatric Research
Volume	87
Issue number	Suppl 1
DOIs	https://doi.org/10.1038/s41390-020-0777-x https://doi.org/10.1038/s41390-020-0777-x
Publication status	Published - Mar 2020

Bibliographical note

Funding Information:
Competing interests: A.P. has received funding from Chiesi. The authors have declared no competing interests.

Funding Information:
The members of eurUS.brain have read and approved this issue. Funding for this publication was provided by the European Society for Paediatric Research (ESPR).

Publisher Copyright:
© 2020, The Author(s).

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Doppler Ultrasound
Brain Circulation
Preterm Infants
Diagnostic value
predictive value

Access to Document

10.1038/s41390-020-0777-x
10.1038/s41390-020-0777-xLicence: CC BY

Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infantsFinal published version, 1.7 MBLicence: CC BY

Cite this

@article{45cbb54849b24f85ac11617a3d9b6fbb,

title = "Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review",

abstract = "INTRODUCTION: Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.METHODS: A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.RESULTS: In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.DISCUSSION: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.",

keywords = "Doppler Ultrasound, Brain Circulation, Preterm Infants, Diagnostic value, predictive value",

author = "{eurUS.brain group} and Camfferman, {Fleur A} and {de Goederen}, Robbin and Paul Govaert and Jeroen Dudink and {van Bel}, Frank and Adelina Pellicer and Filip Cools",

note = "Funding Information: Competing interests: A.P. has received funding from Chiesi. The authors have declared no competing interests. Funding Information: The members of eurUS.brain have read and approved this issue. Funding for this publication was provided by the European Society for Paediatric Research (ESPR). Publisher Copyright: {\textcopyright} 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = mar,

doi = "10.1038/s41390-020-0777-x",

language = "English",

volume = "87",

pages = "50--58",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Lippincott Williams and Wilkins",

number = "Suppl 1",

}

TY - JOUR

T1 - Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants

T2 - a systematic review

AU - eurUS.brain group

AU - Camfferman, Fleur A

AU - de Goederen, Robbin

AU - Govaert, Paul

AU - Dudink, Jeroen

AU - van Bel, Frank

AU - Pellicer, Adelina

AU - Cools, Filip

N1 - Funding Information: Competing interests: A.P. has received funding from Chiesi. The authors have declared no competing interests. Funding Information: The members of eurUS.brain have read and approved this issue. Funding for this publication was provided by the European Society for Paediatric Research (ESPR). Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/3

Y1 - 2020/3

N2 - INTRODUCTION: Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.METHODS: A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.RESULTS: In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.DISCUSSION: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.

AB - INTRODUCTION: Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.METHODS: A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.RESULTS: In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.DISCUSSION: There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.

KW - Doppler Ultrasound

KW - Brain Circulation

KW - Preterm Infants

KW - Diagnostic value

KW - predictive value

UR - http://www.scopus.com/inward/record.url?scp=85082561745&partnerID=8YFLogxK

U2 - 10.1038/s41390-020-0777-x

DO - 10.1038/s41390-020-0777-x

M3 - Scientific review

C2 - 32218536

SN - 0031-3998

VL - 87

SP - 50

EP - 58

JO - Pediatric Research

JF - Pediatric Research

IS - Suppl 1

ER -

Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: a systematic review

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this