Diagnostic scores predict morbidity and mortality in patients hospitalized for heart failure with preserved ejection fraction

Frederik H Verbrugge, Yogesh N V Reddy, Hidemi Sorimachi, Kazunori Omote, Rickey E Carter, Barry A Borlaug

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Abstract

AIMS: To investigate the prognostic value of diagnostic scores for heart failure with preserved ejection fraction (HFpEF).

METHODS AND RESULTS: Consecutive patients with HFpEF admitted for unequivocal decompensated HF treated with intravenous loop diuretics were evaluated (n=443; 78±12 years; 60% women). The HFA-PEFF and H2 FPEF scores were calculated for all patients with echocardiography data available within 1 year and the population was stratified according to HFA-PEFF scores 2-4 (n=79), 5 (n=93), or 6 (n=271) and H2 FPEF score probabilities <90% (n=80), 90-95% (n=61), and 96-100% (n=293). HF readmission rates (95% confidence intervals) increased from 28.9 (22.7-35.0) per 100 patient-years in HFA-PEFF 2-4 to 46.0 (38.5-53.5) in HFA-PEFF 5 and 45.0 (40.1-49.8) in HFA-PEFF 6. Similarly, HF readmission rates increased with increasing H2 FPEF probability: <0.90 [31.8 (25.3-38.2) per 100 patient-years], 0.90-0.95 [41.5 (32.9-50.1)], and 0.96-1.00 [45.9 (41.2-50.6]. Median survival was 65 months (36-89 months) in HFA-PEFF score 2-4, 45 months (26-59 months) in HFA-PEFF score 5, and 28 months (22-42 months) in HFA-PEFF score 6 (P-value<0.001), while the hazard ratio (95% confidence interval) for all-cause mortality was 1.16 (1.02-1.32) per 0.10 increase in H2 FPEF probability.

CONCLUSIONS: Among patients hospitalized with HFpEF, higher HFpEF probability according to diagnostic scores is associated with increased risk of subsequent HF readmissions and all-cause mortality.

Original languageEnglish
JournalEuropean Journal of Heart Failure
Early online date26 Feb 2021
DOIs
Publication statusPublished - 9 Mar 2021

Bibliographical note

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Keywords

  • cause of death
  • diastolic heart failure
  • mortality
  • patient readmission
  • risk assessment

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