Diaphragm-specific nucleic acid regulatory elements and methods and use thereof

Marinee Chuah (Inventor), Thierry VandenDriessche (Inventor), Warut Tulalamba (Inventor)

Research output: Patent


The present invention relates to nucleic acid regulatory elements that are able to enhance diaphragm-specific expression of genes, in particular expression in diaphragm as such, or in combination with expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly diaphragm-directed gene therapy, and for vaccination purposes.
Original languageEnglish
Patent numberWO2018178067
Publication statusPublished - 2018


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