Differences in intraoperative sampling during meningioma surgery regarding CNS invasion - Results of a survey on behalf of the EANS skull base section

Felix Behling, Michaël Bruneau, Jürgen Honegger, Moncef Berhouma, Emmanuel Jouanneau, Luigi Cavallo, Jan Frederick Cornelius, Mahmoud Messerer, Roy Thomas Daniel, Sébastien Froelich, Diego Mazzatenta, Torstein Meling, Dimitrios Paraskevopoulos, Pierre-Hugues Roche, Henry W S Schroeder, Idoya Zazpe, Eduard Voormolen, Massimiliano Visocchi, Ekkehard Kasper, Jens SchittenhelmMarcos Tatagiba

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Abstract

INTRODUCTION: and Research Question: Invasive growth of meningiomas into CNS tissue is rare but of prognostic significance. While it has entered the WHO classification as a stand-alone criterion for atypia, its true prognostic impact remains controversial. Retrospective analyses, on which the current evidence is based, show conflicting results. Discordant findings might be explained by different intraoperative sampling methodologies.

MATERIAL AND METHODS: To assess the applied sampling methods in the light of the novel prognostic impact of CNS invasion, an anonymous survey was designed and distributed via the EANS website and newsletter. The survey was open from June 5th until July 15th, 2022.

RESULTS: After exclusion of 13 incomplete responses, 142 (91.6%) datasets were used for statistical analysis. Only 47.2% of participants' institutions utilize a standardized sampling method, and 54.9% pursue a complete sampling of the area of contact between the meningioma surface and CNS tissue. Most respondents (77.5%) did not change their sampling practice after introduction of the new grading criteria to the WHO classification of 2016. Intraoperative suspicion of CNS invasion changes the sampling for half of the participants (49.3%). Additional sampling of suspicious areas of interest is reported in 53.5%. Dural attachment and adjacent bone are more readily sampled separately if tumor invasion is suspected (72.5% and 74.6%, respectively), compared to meningioma tissue with signs of CNS invasion (59.9%).

DISCUSSION AND CONCLUSIONS: Intraoperative sampling methods during meningioma resection vary among neurosurgical departments. There is need for a structured sampling to optimize the diagnostic yield of CNS invasion.

Original languageEnglish
Article number101740
JournalBrain and spine
Volume3
Early online date11 Apr 2023
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
We acknowledge support by the Open Access Publishing Fund of the University of Tübingen.

Publisher Copyright:
© 2023 The Authors

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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