DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia, Balint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucia Chemes, Matyas Pajkos, Tamas Lazar, Samuel Pena-Diaz, Jaime Santos, Veronika Acs, Nazanin Farahi, Erzsebet Ficho, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav S. Davidović, László Dobson, Arne ElofssonGabor Erdos, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentin Iglesias, Zsofia Kalman, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino Buslje, Attila Meszaros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F. Nilsson, Marian Novotny, Christos A Ouzounis, Nicolas Palopoli, Elena Papaleo, Pedro Pereira, Gabriele Pozzati, Vasilis J. Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamas Szaniszlo, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C E Tosatto, Damiano Piovesan

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Original languageEnglish
Pages (from-to)D480-D487
Number of pages8
JournalNucleic Acids Research
Issue numberD1
Publication statusPublished - 7 Jan 2022

Bibliographical note

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.


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