DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia; Balint Mészáros; Edoardo Salladini; András Hatos; Rita Pancsa; Lucia Chemes; Matyas Pajkos; Tamas Lazar; Samuel Pena-Diaz; Jaime Santos; Veronika Acs; Nazanin Farahi; Erzsebet Ficho; Maria Cristina Aspromonte; Claudio Bassot; Anastasia Chasapi; Norman E Davey; Radoslav S. Davidović; László Dobson; Arne Elofsson; Gabor Erdos; Pascale Gaudet; Michelle Giglio; Juliana Glavina; Javier Iserte; Valentin Iglesias; Zsofia Kalman; Matteo Lambrughi; Emanuela Leonardi; Sonia Longhi; Sandra Macedo-Ribeiro; Emiliano Maiani; Julia Marchetti; Cristina Marino Buslje; Attila Meszaros; Alexander Miguel Monzon; Giovanni Minervini; Suvarna Nadendla; Juliet F. Nilsson; Marian Novotny; Christos A Ouzounis; Nicolas Palopoli; Elena Papaleo; Pedro Pereira; Gabriele Pozzati; Vasilis J. Promponas; Jordi Pujols; Alma Carolina Sanchez Rocha; Martin Salas; Luciana Rodriguez Sawicki; Eva Schad; Aditi Shenoy; Tamas Szaniszlo; Konstantinos D Tsirigos; Nevena Veljkovic; Gustavo Parisi; Salvador Ventura; Zsuzsanna Dosztányi; Peter Tompa; Silvio C E Tosatto; Damiano Piovesan

doi:10.1093/nar/gkab1082

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia, Balint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucia Chemes, Matyas Pajkos, Tamas Lazar, Samuel Pena-Diaz, Jaime Santos, Veronika Acs, Nazanin Farahi, Erzsebet Ficho, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav S. Davidović, László Dobson, Arne ElofssonGabor Erdos, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentin Iglesias, Zsofia Kalman, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino Buslje, Attila Meszaros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F. Nilsson, Marian Novotny, Christos A Ouzounis, Nicolas Palopoli, Elena Papaleo, Pedro Pereira, Gabriele Pozzati, Vasilis J. Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamas Szaniszlo, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C E Tosatto, Damiano Piovesan

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Original language	English
Pages (from-to)	D480-D487
Number of pages	8
Journal	Nucleic Acids Research
Volume	50
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkab1082
Publication status	Published - 7 Jan 2022

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10.1093/nar/gkab1082Licence: CC BY

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Quaglia, F., Mészáros, B., Salladini, E., Hatos, A., Pancsa, R., Chemes, L., Pajkos, M., Lazar, T., Pena-Diaz, S., Santos, J., Acs, V., Farahi, N., Ficho, E., Aspromonte, M. C., Bassot, C., Chasapi, A., Davey, N. E., Davidović, R. S., Dobson, L., ... Piovesan, D. (2022). DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Research, 50(D1), D480-D487. https://doi.org/10.1093/nar/gkab1082

Quaglia, Federica ; Mészáros, Balint ; Salladini, Edoardo ; Hatos, András ; Pancsa, Rita ; Chemes, Lucia ; Pajkos, Matyas ; Lazar, Tamas ; Pena-Diaz, Samuel ; Santos, Jaime ; Acs, Veronika ; Farahi, Nazanin ; Ficho, Erzsebet ; Aspromonte, Maria Cristina ; Bassot, Claudio ; Chasapi, Anastasia ; Davey, Norman E ; Davidović, Radoslav S. ; Dobson, László ; Elofsson, Arne ; Erdos, Gabor ; Gaudet, Pascale ; Giglio, Michelle ; Glavina, Juliana ; Iserte, Javier ; Iglesias, Valentin ; Kalman, Zsofia ; Lambrughi, Matteo ; Leonardi, Emanuela ; Longhi, Sonia ; Macedo-Ribeiro, Sandra ; Maiani, Emiliano ; Marchetti, Julia ; Marino Buslje, Cristina ; Meszaros, Attila ; Monzon, Alexander Miguel ; Minervini, Giovanni ; Nadendla, Suvarna ; Nilsson, Juliet F. ; Novotny, Marian ; Ouzounis, Christos A ; Palopoli, Nicolas ; Papaleo, Elena ; Pereira, Pedro ; Pozzati, Gabriele ; Promponas, Vasilis J. ; Pujols, Jordi ; Sanchez Rocha, Alma Carolina ; Salas, Martin ; Rodriguez Sawicki, Luciana ; Schad, Eva ; Shenoy, Aditi ; Szaniszlo, Tamas ; Tsirigos, Konstantinos D ; Veljkovic, Nevena ; Parisi, Gustavo ; Ventura, Salvador ; Dosztányi, Zsuzsanna ; Tompa, Peter ; Tosatto, Silvio C E ; Piovesan, Damiano. / DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. In: Nucleic Acids Research. 2022 ; Vol. 50, No. D1. pp. D480-D487.

@article{725a17dd210d4de0b1791708fa0fd73e,

title = "DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation",

abstract = "The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.",

author = "Federica Quaglia and Balint M{\'e}sz{\'a}ros and Edoardo Salladini and Andr{\'a}s Hatos and Rita Pancsa and Lucia Chemes and Matyas Pajkos and Tamas Lazar and Samuel Pena-Diaz and Jaime Santos and Veronika Acs and Nazanin Farahi and Erzsebet Ficho and Aspromonte, {Maria Cristina} and Claudio Bassot and Anastasia Chasapi and Davey, {Norman E} and Davidovi{\'c}, {Radoslav S.} and L{\'a}szl{\'o} Dobson and Arne Elofsson and Gabor Erdos and Pascale Gaudet and Michelle Giglio and Juliana Glavina and Javier Iserte and Valentin Iglesias and Zsofia Kalman and Matteo Lambrughi and Emanuela Leonardi and Sonia Longhi and Sandra Macedo-Ribeiro and Emiliano Maiani and Julia Marchetti and {Marino Buslje}, Cristina and Attila Meszaros and Monzon, {Alexander Miguel} and Giovanni Minervini and Suvarna Nadendla and Nilsson, {Juliet F.} and Marian Novotny and Ouzounis, {Christos A} and Nicolas Palopoli and Elena Papaleo and Pedro Pereira and Gabriele Pozzati and Promponas, {Vasilis J.} and Jordi Pujols and {Sanchez Rocha}, {Alma Carolina} and Martin Salas and {Rodriguez Sawicki}, Luciana and Eva Schad and Aditi Shenoy and Tamas Szaniszlo and Tsirigos, {Konstantinos D} and Nevena Veljkovic and Gustavo Parisi and Salvador Ventura and Zsuzsanna Doszt{\'a}nyi and Peter Tompa and Tosatto, {Silvio C E} and Damiano Piovesan",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.",

year = "2022",

month = jan,

day = "7",

doi = "10.1093/nar/gkab1082",

language = "English",

volume = "50",

pages = "D480--D487",

journal = "Nucleic Acids Res",

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number = "D1",

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Quaglia, F, Mészáros, B, Salladini, E, Hatos, A, Pancsa, R, Chemes, L, Pajkos, M, Lazar, T, Pena-Diaz, S, Santos, J, Acs, V, Farahi, N, Ficho, E, Aspromonte, MC, Bassot, C, Chasapi, A, Davey, NE, Davidović, RS, Dobson, L, Elofsson, A, Erdos, G, Gaudet, P, Giglio, M, Glavina, J, Iserte, J, Iglesias, V, Kalman, Z, Lambrughi, M, Leonardi, E, Longhi, S, Macedo-Ribeiro, S, Maiani, E, Marchetti, J, Marino Buslje, C, Meszaros, A, Monzon, AM, Minervini, G, Nadendla, S, Nilsson, JF, Novotny, M, Ouzounis, CA, Palopoli, N, Papaleo, E, Pereira, P, Pozzati, G, Promponas, VJ, Pujols, J, Sanchez Rocha, AC, Salas, M, Rodriguez Sawicki, L, Schad, E, Shenoy, A, Szaniszlo, T, Tsirigos, KD, Veljkovic, N, Parisi, G, Ventura, S, Dosztányi, Z, Tompa, P, Tosatto, SCE & Piovesan, D 2022, 'DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation', Nucleic Acids Research, vol. 50, no. D1, pp. D480-D487. https://doi.org/10.1093/nar/gkab1082

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. / Quaglia, Federica; Mészáros, Balint; Salladini, Edoardo; Hatos, András; Pancsa, Rita; Chemes, Lucia; Pajkos, Matyas; Lazar, Tamas; Pena-Diaz, Samuel; Santos, Jaime; Acs, Veronika; Farahi, Nazanin; Ficho, Erzsebet; Aspromonte, Maria Cristina; Bassot, Claudio; Chasapi, Anastasia; Davey, Norman E; Davidović, Radoslav S.; Dobson, László; Elofsson, Arne; Erdos, Gabor; Gaudet, Pascale; Giglio, Michelle; Glavina, Juliana; Iserte, Javier; Iglesias, Valentin; Kalman, Zsofia; Lambrughi, Matteo; Leonardi, Emanuela; Longhi, Sonia; Macedo-Ribeiro, Sandra; Maiani, Emiliano; Marchetti, Julia; Marino Buslje, Cristina; Meszaros, Attila; Monzon, Alexander Miguel; Minervini, Giovanni; Nadendla, Suvarna; Nilsson, Juliet F.; Novotny, Marian; Ouzounis, Christos A; Palopoli, Nicolas; Papaleo, Elena; Pereira, Pedro; Pozzati, Gabriele; Promponas, Vasilis J.; Pujols, Jordi; Sanchez Rocha, Alma Carolina; Salas, Martin; Rodriguez Sawicki, Luciana; Schad, Eva; Shenoy, Aditi; Szaniszlo, Tamas; Tsirigos, Konstantinos D; Veljkovic, Nevena; Parisi, Gustavo; Ventura, Salvador; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C E; Piovesan, Damiano.

In: Nucleic Acids Research, Vol. 50, No. D1, 07.01.2022, p. D480-D487.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

AU - Quaglia, Federica

AU - Mészáros, Balint

AU - Salladini, Edoardo

AU - Hatos, András

AU - Pancsa, Rita

AU - Chemes, Lucia

AU - Pajkos, Matyas

AU - Lazar, Tamas

AU - Pena-Diaz, Samuel

AU - Santos, Jaime

AU - Acs, Veronika

AU - Farahi, Nazanin

AU - Ficho, Erzsebet

AU - Aspromonte, Maria Cristina

AU - Bassot, Claudio

AU - Chasapi, Anastasia

AU - Davey, Norman E

AU - Davidović, Radoslav S.

AU - Dobson, László

AU - Elofsson, Arne

AU - Erdos, Gabor

AU - Gaudet, Pascale

AU - Giglio, Michelle

AU - Glavina, Juliana

AU - Iserte, Javier

AU - Iglesias, Valentin

AU - Kalman, Zsofia

AU - Lambrughi, Matteo

AU - Leonardi, Emanuela

AU - Longhi, Sonia

AU - Macedo-Ribeiro, Sandra

AU - Maiani, Emiliano

AU - Marchetti, Julia

AU - Marino Buslje, Cristina

AU - Meszaros, Attila

AU - Monzon, Alexander Miguel

AU - Minervini, Giovanni

AU - Nadendla, Suvarna

AU - Nilsson, Juliet F.

AU - Novotny, Marian

AU - Ouzounis, Christos A

AU - Palopoli, Nicolas

AU - Papaleo, Elena

AU - Pereira, Pedro

AU - Pozzati, Gabriele

AU - Promponas, Vasilis J.

AU - Pujols, Jordi

AU - Sanchez Rocha, Alma Carolina

AU - Salas, Martin

AU - Rodriguez Sawicki, Luciana

AU - Schad, Eva

AU - Shenoy, Aditi

AU - Szaniszlo, Tamas

AU - Tsirigos, Konstantinos D

AU - Veljkovic, Nevena

AU - Parisi, Gustavo

AU - Ventura, Salvador

AU - Dosztányi, Zsuzsanna

AU - Tompa, Peter

AU - Tosatto, Silvio C E

AU - Piovesan, Damiano

PY - 2022/1/7

Y1 - 2022/1/7

N2 - The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

AB - The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

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U2 - 10.1093/nar/gkab1082

DO - 10.1093/nar/gkab1082

M3 - Article

C2 - 34850135

VL - 50

SP - D480-D487

JO - Nucleic Acids Res

JF - Nucleic Acids Res

SN - 0305-1048

IS - D1

ER -

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

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