Double versus single intrauterine insemination for unexplained infertility: a meta-analysis of randomized trials

Nikolaos P Polyzos, Spyridon Tzioras, Davide Mauri, Athina Tatsioni

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility.

DESIGN: Meta-analysis of randomized controlled trials.

MAIN OUTCOME MEASURE(S): Clinical pregnancy rates per couple.

INTERVENTION(S): Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction through March 2009; hand searching of the abstract books of the European Society of Human Reproduction and Embryology and American Society for Reproductive Medicine annual meetings (2001-2008).

RESULT(S): Six randomized trials, involving 829 women, were included in the analysis. Fifty-four (13.6%) clinical pregnancies were recorded for treatment with double IUI and 62 (14.4%) for treatment with single IUI. There was no significant difference between the single and double IUI groups in the probability for clinical pregnancy (odds ratio, 0.92; 95% confidence interval, 0.58-1.45; P=0.715).

CONCLUSION(S): Double IUI offers no clear benefit in the overall clinical pregnancy rate in couples with unexplained infertility.

Original languageEnglish
Pages (from-to)1261-1266
Number of pages6
JournalFertility and Sterility
Volume94
Issue number4
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Adult
  • Algorithms
  • Family Characteristics
  • Female
  • Geography
  • Humans
  • Infertility
  • Insemination, Artificial
  • Male
  • Pregnancy
  • Pregnancy Rate
  • Quality Control
  • Randomized Controlled Trials as Topic
  • Uterus

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