Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

Roberta Manganaro; Stella Marchetta; Raluca Dulgheru; Federica Ilardi; Tadafumi Sugimoto; Sebastien Robinet; Sara Cimino; Yun Yun Go; Anne Bernard; George Kacharava; George D. Athanassopoulos; Daniele Barone; Monica Baroni; Nuno Cardim; Andreas Hagendorff; Krasimira Hristova; Teresa Lopez-Fernandez; Gonzalo de la Morena; Bogdan A. Popescu; Martin Penicka; Tolga Ozyigit; Jose David Rodrigo Carbonero; Nico van de Veire; Ralph Stephan Von Bardeleben; Dragos Vinereanu; Jose Luis Zamorano; Monica Rosca; Andreea Calin; Marie Moonen; Julien Magne; Bernard Cosyns; Elena Galli; Erwan Donal; Scipione Carerj; Concetta Zito; Ciro Santoro; Maurizio Galderisi; Luigi P. Badano; Roberto M. Lang; Cecile Oury; Patrizio Lancellotti

doi:10.1093/ehjci/jey188

Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

Roberta Manganaro, Stella Marchetta, Raluca Dulgheru, Federica Ilardi, Tadafumi Sugimoto, Sebastien Robinet, Sara Cimino, Yun Yun Go, Anne Bernard, George Kacharava, George D. Athanassopoulos, Daniele Barone, Monica Baroni, Nuno Cardim, Andreas Hagendorff, Krasimira Hristova, Teresa Lopez-Fernandez, Gonzalo de la Morena, Bogdan A. Popescu, Martin PenickaTolga Ozyigit, Jose David Rodrigo Carbonero, Nico van de Veire, Ralph Stephan Von Bardeleben, Dragos Vinereanu, Jose Luis Zamorano, Monica Rosca, Andreea Calin, Marie Moonen, Julien Magne, Bernard Cosyns, Elena Galli, Erwan Donal, Scipione Carerj, Concetta Zito, Ciro Santoro, Maurizio Galderisi, Luigi P. Badano, Roberto M. Lang, Cecile Oury, Patrizio Lancellotti

Research output: Contribution to journal › Article › peer-review

249 Citations (Scopus)

Abstract

Aims To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender.

Methods and results A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270mmHg% and 1310mmHg% for GWI, 1650mmHg% and 1544mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238mmHg% in men and 239mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women.

Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

Original language	English
Article number	jey188
Pages (from-to)	582-590
Number of pages	9
Journal	European Heart Journal. Cardiovascular Imaging
Volume	20
Issue number	5
DOIs	https://doi.org/10.1093/ehjci/jey188
Publication status	Published - May 2019

Keywords

adult echocardiography
2D echocardiography
myocardial work
reference values

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10.1093/ehjci/jey188

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Manganaro, R., Marchetta, S., Dulgheru, R., Ilardi, F., Sugimoto, T., Robinet, S., Cimino, S., Go, Y. Y., Bernard, A., Kacharava, G., Athanassopoulos, G. D., Barone, D., Baroni, M., Cardim, N., Hagendorff, A., Hristova, K., Lopez-Fernandez, T., de la Morena, G., Popescu, B. A., ... Lancellotti, P. (2019). Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study. European Heart Journal. Cardiovascular Imaging, 20(5), 582-590. [jey188]. https://doi.org/10.1093/ehjci/jey188

Manganaro, Roberta ; Marchetta, Stella ; Dulgheru, Raluca ; Ilardi, Federica ; Sugimoto, Tadafumi ; Robinet, Sebastien ; Cimino, Sara ; Go, Yun Yun ; Bernard, Anne ; Kacharava, George ; Athanassopoulos, George D. ; Barone, Daniele ; Baroni, Monica ; Cardim, Nuno ; Hagendorff, Andreas ; Hristova, Krasimira ; Lopez-Fernandez, Teresa ; de la Morena, Gonzalo ; Popescu, Bogdan A. ; Penicka, Martin ; Ozyigit, Tolga ; Rodrigo Carbonero, Jose David ; van de Veire, Nico ; Von Bardeleben, Ralph Stephan ; Vinereanu, Dragos ; Zamorano, Jose Luis ; Rosca, Monica ; Calin, Andreea ; Moonen, Marie ; Magne, Julien ; Cosyns, Bernard ; Galli, Elena ; Donal, Erwan ; Carerj, Scipione ; Zito, Concetta ; Santoro, Ciro ; Galderisi, Maurizio ; Badano, Luigi P. ; Lang, Roberto M. ; Oury, Cecile ; Lancellotti, Patrizio. / Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study. In: European Heart Journal. Cardiovascular Imaging. 2019 ; Vol. 20, No. 5. pp. 582-590.

@article{8e3380f923d44dfd82e1699024a7aa73,

title = "Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study",

abstract = "Aims To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270mmHg% and 1310mmHg% for GWI, 1650mmHg% and 1544mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238mmHg% in men and 239mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.",

keywords = "adult echocardiography, 2D echocardiography, myocardial work, reference values",

author = "Roberta Manganaro and Stella Marchetta and Raluca Dulgheru and Federica Ilardi and Tadafumi Sugimoto and Sebastien Robinet and Sara Cimino and Go, {Yun Yun} and Anne Bernard and George Kacharava and Athanassopoulos, {George D.} and Daniele Barone and Monica Baroni and Nuno Cardim and Andreas Hagendorff and Krasimira Hristova and Teresa Lopez-Fernandez and {de la Morena}, Gonzalo and Popescu, {Bogdan A.} and Martin Penicka and Tolga Ozyigit and {Rodrigo Carbonero}, {Jose David} and {van de Veire}, Nico and {Von Bardeleben}, {Ralph Stephan} and Dragos Vinereanu and Zamorano, {Jose Luis} and Monica Rosca and Andreea Calin and Marie Moonen and Julien Magne and Bernard Cosyns and Elena Galli and Erwan Donal and Scipione Carerj and Concetta Zito and Ciro Santoro and Maurizio Galderisi and Badano, {Luigi P.} and Lang, {Roberto M.} and Cecile Oury and Patrizio Lancellotti",

year = "2019",

month = may,

doi = "10.1093/ehjci/jey188",

language = "English",

volume = "20",

pages = "582--590",

journal = "European Heart Journal. Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "5",

}

Manganaro, R, Marchetta, S, Dulgheru, R, Ilardi, F, Sugimoto, T, Robinet, S, Cimino, S, Go, YY, Bernard, A, Kacharava, G, Athanassopoulos, GD, Barone, D, Baroni, M, Cardim, N, Hagendorff, A, Hristova, K, Lopez-Fernandez, T, de la Morena, G, Popescu, BA, Penicka, M, Ozyigit, T, Rodrigo Carbonero, JD, van de Veire, N, Von Bardeleben, RS, Vinereanu, D, Zamorano, JL, Rosca, M, Calin, A, Moonen, M, Magne, J , Cosyns, B, Galli, E, Donal, E, Carerj, S, Zito, C, Santoro, C, Galderisi, M, Badano, LP, Lang, RM, Oury, C & Lancellotti, P 2019, 'Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study', European Heart Journal. Cardiovascular Imaging, vol. 20, no. 5, jey188, pp. 582-590. https://doi.org/10.1093/ehjci/jey188

Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study. / Manganaro, Roberta; Marchetta, Stella; Dulgheru, Raluca; Ilardi, Federica; Sugimoto, Tadafumi; Robinet, Sebastien; Cimino, Sara; Go, Yun Yun; Bernard, Anne; Kacharava, George; Athanassopoulos, George D.; Barone, Daniele; Baroni, Monica; Cardim, Nuno; Hagendorff, Andreas; Hristova, Krasimira; Lopez-Fernandez, Teresa; de la Morena, Gonzalo; Popescu, Bogdan A.; Penicka, Martin; Ozyigit, Tolga; Rodrigo Carbonero, Jose David; van de Veire, Nico; Von Bardeleben, Ralph Stephan; Vinereanu, Dragos; Zamorano, Jose Luis; Rosca, Monica; Calin, Andreea; Moonen, Marie; Magne, Julien ; Cosyns, Bernard; Galli, Elena; Donal, Erwan; Carerj, Scipione; Zito, Concetta; Santoro, Ciro; Galderisi, Maurizio; Badano, Luigi P.; Lang, Roberto M.; Oury, Cecile; Lancellotti, Patrizio.

In: European Heart Journal. Cardiovascular Imaging, Vol. 20, No. 5, jey188, 05.2019, p. 582-590.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

AU - Manganaro, Roberta

AU - Marchetta, Stella

AU - Dulgheru, Raluca

AU - Ilardi, Federica

AU - Sugimoto, Tadafumi

AU - Robinet, Sebastien

AU - Cimino, Sara

AU - Go, Yun Yun

AU - Bernard, Anne

AU - Kacharava, George

AU - Athanassopoulos, George D.

AU - Barone, Daniele

AU - Baroni, Monica

AU - Cardim, Nuno

AU - Hagendorff, Andreas

AU - Hristova, Krasimira

AU - Lopez-Fernandez, Teresa

AU - de la Morena, Gonzalo

AU - Popescu, Bogdan A.

AU - Penicka, Martin

AU - Ozyigit, Tolga

AU - Rodrigo Carbonero, Jose David

AU - van de Veire, Nico

AU - Von Bardeleben, Ralph Stephan

AU - Vinereanu, Dragos

AU - Zamorano, Jose Luis

AU - Rosca, Monica

AU - Calin, Andreea

AU - Moonen, Marie

AU - Magne, Julien

AU - Cosyns, Bernard

AU - Galli, Elena

AU - Donal, Erwan

AU - Carerj, Scipione

AU - Zito, Concetta

AU - Santoro, Ciro

AU - Galderisi, Maurizio

AU - Badano, Luigi P.

AU - Lang, Roberto M.

AU - Oury, Cecile

AU - Lancellotti, Patrizio

PY - 2019/5

Y1 - 2019/5

N2 - Aims To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270mmHg% and 1310mmHg% for GWI, 1650mmHg% and 1544mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238mmHg% in men and 239mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

AB - Aims To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270mmHg% and 1310mmHg% for GWI, 1650mmHg% and 1544mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238mmHg% in men and 239mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

KW - adult echocardiography

KW - 2D echocardiography

KW - myocardial work

KW - reference values

UR - http://www.scopus.com/inward/record.url?scp=85068205398&partnerID=8YFLogxK

U2 - 10.1093/ehjci/jey188

DO - 10.1093/ehjci/jey188

M3 - Article

VL - 20

SP - 582

EP - 590

JO - European Heart Journal. Cardiovascular Imaging

JF - European Heart Journal. Cardiovascular Imaging

SN - 2047-2404

IS - 5

M1 - jey188

ER -

Echocardiographic reference ranges for normal non-invasive myocardial work indices: results from the EACVI NORRE study

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