Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro

Bárbara Nery Enes; Luiza De Paula Dias Moreira; Renata Celi Lopes Toledo; Érica Aguiar Moraes; Maria Eliza de Castro Moreira; Helen Hermana Miranda Hermsdorf; Giuliana  Noratto; Susanne Ursula  Mertens-Talcott; Stephen Stephen Talcottd; Hércia Stampini Duarte Martino

doi:10.1016/j.jff.2020.104026

Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro

Bárbara Nery Enes, Luiza De Paula Dias Moreira, Renata Celi Lopes Toledo, Érica Aguiar Moraes, Maria Eliza de Castro Moreira, Helen Hermana Miranda Hermsdorf, Giuliana Noratto, Susanne Ursula Mertens-Talcott, Stephen Stephen Talcottd, Hércia Stampini Duarte Martino

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Abstract

The influence of chia (Salvia hispanica L.) flour and oil on glucose metabolism (GM) in insulin resistant (IR) Wistar rats and the effect of chia hydrolyzed phenolics extract (CHPE) on GM in IR HepG2 cells were evaluated. In vivo study: animals were divided into four groups: AIN-93M, high-fat and high-fructose (HFHF), HFHF with chia flour (14.7%) or chia oil (4%). In vitro study: IR HepG2 cells were treated with CHPE (80 ppm). In vivo, chia flour and oil reduced adiposity and increased AMPK mRNA. Chia oil improved glucose tolerance, increased AKT1[pS473] protein level, mRNA of insulin receptor, FOXO1 and glycolysis enzymes. In vitro, CHPE decreased gluconeogenesis enzymes mRNA. Chia flour and oil decreased adiposity, but only chia oil was able to improve glucose tolerance and restore energy fuel system in liver of rats fed HFHF diet. CHPE decreased mRNA levels of gluconeogenesis enzymes.

Original language	English
Article number	104026
Number of pages	11
Journal	Journal of functional foods
Volume	71
DOIs	https://doi.org/10.1016/j.jff.2020.104026
Publication status	Published - Aug 2020
Externally published	Yes

Bibliographical note

Funding Information:
The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N° 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support ( 88881.190055/2018-01 ); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil).

Funding Information:
The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N? 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support (88881.190055/2018-01); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil).

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© 2020

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Enes, B. N., De Paula Dias Moreira, L., Toledo, R. C. L., Aguiar Moraes, É., de Castro Moreira, M. E., Hermana Miranda Hermsdorf, H., Noratto, G., Mertens-Talcott, S. U., Stephen Talcottd, S., & Stampini Duarte Martino, H. (2020). Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro. Journal of functional foods, 71, Article 104026. https://doi.org/10.1016/j.jff.2020.104026

@article{a7091b42499d4e4383ea1de79afce326,

title = "Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro",

abstract = "The influence of chia (Salvia hispanica L.) flour and oil on glucose metabolism (GM) in insulin resistant (IR) Wistar rats and the effect of chia hydrolyzed phenolics extract (CHPE) on GM in IR HepG2 cells were evaluated. In vivo study: animals were divided into four groups: AIN-93M, high-fat and high-fructose (HFHF), HFHF with chia flour (14.7%) or chia oil (4%). In vitro study: IR HepG2 cells were treated with CHPE (80 ppm). In vivo, chia flour and oil reduced adiposity and increased AMPK mRNA. Chia oil improved glucose tolerance, increased AKT1[pS473] protein level, mRNA of insulin receptor, FOXO1 and glycolysis enzymes. In vitro, CHPE decreased gluconeogenesis enzymes mRNA. Chia flour and oil decreased adiposity, but only chia oil was able to improve glucose tolerance and restore energy fuel system in liver of rats fed HFHF diet. CHPE decreased mRNA levels of gluconeogenesis enzymes.",

author = "Enes, {B{\'a}rbara Nery} and {De Paula Dias Moreira}, Luiza and Toledo, {Renata Celi Lopes} and {Aguiar Moraes}, {\'E}rica and {de Castro Moreira}, {Maria Eliza} and {Hermana Miranda Hermsdorf}, Helen and Giuliana Noratto and Mertens-Talcott, {Susanne Ursula} and {Stephen Talcottd}, Stephen and {Stampini Duarte Martino}, H{\'e}rcia",

note = "Funding Information: The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N° 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support ( 88881.190055/2018-01 ); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil). Funding Information: The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N? 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support (88881.190055/2018-01); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil). Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = aug,

doi = "10.1016/j.jff.2020.104026",

language = "English",

volume = "71",

journal = "Journal of functional foods",

issn = "1756-4646",

publisher = "Elsevier",

}

Enes, BN, De Paula Dias Moreira, L, Toledo, RCL, Aguiar Moraes, É, de Castro Moreira, ME, Hermana Miranda Hermsdorf, H, Noratto, G, Mertens-Talcott, SU, Stephen Talcottd, S & Stampini Duarte Martino, H 2020, 'Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro', Journal of functional foods, vol. 71, 104026. https://doi.org/10.1016/j.jff.2020.104026

TY - JOUR

T1 - Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro

AU - Enes, Bárbara Nery

AU - De Paula Dias Moreira, Luiza

AU - Toledo, Renata Celi Lopes

AU - Aguiar Moraes, Érica

AU - de Castro Moreira, Maria Eliza

AU - Hermana Miranda Hermsdorf, Helen

AU - Noratto, Giuliana

AU - Mertens-Talcott, Susanne Ursula

AU - Stephen Talcottd, Stephen

AU - Stampini Duarte Martino, Hércia

N1 - Funding Information: The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N° 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support ( 88881.190055/2018-01 ); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil). Funding Information: The authors would like to thank the National Cousel of Technological and Scientific Development (CNPq, Brazil) for research support (MCTIC/CNPq N? 28/2018 - Universal - 406517/2018-5); the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) for Scholarship Research support (88881.190055/2018-01); and Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil). Publisher Copyright: © 2020

PY - 2020/8

Y1 - 2020/8

N2 - The influence of chia (Salvia hispanica L.) flour and oil on glucose metabolism (GM) in insulin resistant (IR) Wistar rats and the effect of chia hydrolyzed phenolics extract (CHPE) on GM in IR HepG2 cells were evaluated. In vivo study: animals were divided into four groups: AIN-93M, high-fat and high-fructose (HFHF), HFHF with chia flour (14.7%) or chia oil (4%). In vitro study: IR HepG2 cells were treated with CHPE (80 ppm). In vivo, chia flour and oil reduced adiposity and increased AMPK mRNA. Chia oil improved glucose tolerance, increased AKT1[pS473] protein level, mRNA of insulin receptor, FOXO1 and glycolysis enzymes. In vitro, CHPE decreased gluconeogenesis enzymes mRNA. Chia flour and oil decreased adiposity, but only chia oil was able to improve glucose tolerance and restore energy fuel system in liver of rats fed HFHF diet. CHPE decreased mRNA levels of gluconeogenesis enzymes.

AB - The influence of chia (Salvia hispanica L.) flour and oil on glucose metabolism (GM) in insulin resistant (IR) Wistar rats and the effect of chia hydrolyzed phenolics extract (CHPE) on GM in IR HepG2 cells were evaluated. In vivo study: animals were divided into four groups: AIN-93M, high-fat and high-fructose (HFHF), HFHF with chia flour (14.7%) or chia oil (4%). In vitro study: IR HepG2 cells were treated with CHPE (80 ppm). In vivo, chia flour and oil reduced adiposity and increased AMPK mRNA. Chia oil improved glucose tolerance, increased AKT1[pS473] protein level, mRNA of insulin receptor, FOXO1 and glycolysis enzymes. In vitro, CHPE decreased gluconeogenesis enzymes mRNA. Chia flour and oil decreased adiposity, but only chia oil was able to improve glucose tolerance and restore energy fuel system in liver of rats fed HFHF diet. CHPE decreased mRNA levels of gluconeogenesis enzymes.

UR - http://dx.doi.org/10.1016/j.jff.2020.104026

UR - http://www.scopus.com/inward/record.url?scp=85085219404&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2020.104026

DO - 10.1016/j.jff.2020.104026

M3 - Article

SN - 1756-4646

VL - 71

JO - Journal of functional foods

JF - Journal of functional foods

M1 - 104026

ER -

Effect of different fractions of chia (Salvia hispanica L.) on glucose metabolism, in vivo and in vitro

Abstract

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