Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)

Mohammad Rahimi-Gorji; Ghader Ghorbaniasl; Sarah Cosyns; Wouter Willaert; Wim  Ceelen

Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)

Mohammad Rahimi-Gorji, Ghader Ghorbaniasl, Sarah Cosyns, Wouter Willaert, Wim Ceelen

Applied Mechanics

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research

Abstract

Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.

Original language	English
Title of host publication	26th Congress of the European Society of Biomechanics (ESB 2021)
Subtitle of host publication	European Society of Biomechanics
Place of Publication	Milan, Italy
Publication status	Published - 2021

Cite this

@inproceedings{21ee3df9fc8d4ad8ae93592c23481485,

title = "Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)",

abstract = "Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.",

author = "Mohammad Rahimi-Gorji and Ghader Ghorbaniasl and Sarah Cosyns and Wouter Willaert and Wim Ceelen",

year = "2021",

language = "English",

booktitle = "26th Congress of the European Society of Biomechanics (ESB 2021)",

}

Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC). / Rahimi-Gorji, Mohammad; Ghorbaniasl, Ghader; Cosyns, Sarah; Willaert, Wouter; Ceelen, Wim .

26th Congress of the European Society of Biomechanics (ESB 2021): European Society of Biomechanics. Milan, Italy, 2021.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Research

TY - GEN

T1 - Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)

AU - Rahimi-Gorji, Mohammad

AU - Ghorbaniasl, Ghader

AU - Cosyns, Sarah

AU - Willaert, Wouter

AU - Ceelen, Wim

PY - 2021

Y1 - 2021

N2 - Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.

AB - Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.

UR - http://hdl.handle.net/1854/LU-8714242

M3 - Conference paper

BT - 26th Congress of the European Society of Biomechanics (ESB 2021)

CY - Milan, Italy

ER -

Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)

Abstract

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