Effect of fluid flow rate and droplet size on spatial aerosol distribution during pressurized intraperiational aerosol chemotherapy (PIPAC)

Mohammad Rahimi-Gorji, Ghader Ghorbaniasl, Sarah Cosyns, Wouter Willaert, Wim Ceelen

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.
Original languageEnglish
Title of host publication26th Congress of the European Society of Biomechanics (ESB 2021)
Subtitle of host publicationEuropean Society of Biomechanics
Place of PublicationMilan, Italy
Publication statusPublished - 2021

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