Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative drug delivery platform has developed to treat patients with peritoneal metastases using laparoscopy. During PIPAC, a CO2 pneumoperitoneum is established (12 mmHg) to inflate the abdomen, after which a high-pressure injector delivers the chemotherapy through a nebulizer into the peritoneal cavity. However, some key questions on the ideal technical setup remain unaddressed. Computational fluid dynamics (CFD) allows to study the effects of flow rates and aerosol droplet size on the homogeneity of aerosol distribution.
|Title of host publication||26th Congress of the European Society of Biomechanics (ESB 2021)|
|Subtitle of host publication||European Society of Biomechanics|
|Place of Publication||Milan, Italy|
|Publication status||Published - 2021|