Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer

Nam P Nguyen; M Ceizyk; Fabio Almeida; Alexander Chi; Michael Betz; Homayoun Moderrasifar; Thomas Sroka; Deirdre Cohen; Siyoung Jang; Dave Abraham; Michele Stevie; Lexie Smith-Raymond; Shane P Krafft; Vincent Vinh-Hung

Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer

Nam P Nguyen, M Ceizyk, Fabio Almeida, Alexander Chi, Michael Betz, Homayoun Moderrasifar, Thomas Sroka, Deirdre Cohen, Siyoung Jang, Dave Abraham, Michele Stevie, Lexie Smith-Raymond, Shane P Krafft, Vincent Vinh-Hung

Medical Imaging and Physical Sciences

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10 Citations (Scopus)

Abstract

BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer.

METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted.

RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively.

CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.

Original language	English
Pages (from-to)	380-385
Journal	Ann Surg Oncol
Volume	18
Issue number	2
Publication status	Published - Feb 2011

Keywords

rectal cancer
radiotherapy

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@article{9083f1805d3c462f9461783025eb0e56,

title = "Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer",

abstract = "BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.",

keywords = "rectal cancer, radiotherapy",

author = "Nguyen, {Nam P} and M Ceizyk and Fabio Almeida and Alexander Chi and Michael Betz and Homayoun Moderrasifar and Thomas Sroka and Deirdre Cohen and Siyoung Jang and Dave Abraham and Michele Stevie and Lexie Smith-Raymond and Krafft, {Shane P} and Vincent Vinh-Hung",

year = "2011",

month = feb,

language = "English",

volume = "18",

pages = "380--385",

journal = "Ann Surg Oncol",

issn = "1068-9265",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer

AU - Nguyen, Nam P

AU - Ceizyk, M

AU - Almeida, Fabio

AU - Chi, Alexander

AU - Betz, Michael

AU - Moderrasifar, Homayoun

AU - Sroka, Thomas

AU - Cohen, Deirdre

AU - Jang, Siyoung

AU - Abraham, Dave

AU - Stevie, Michele

AU - Smith-Raymond, Lexie

AU - Krafft, Shane P

AU - Vinh-Hung, Vincent

PY - 2011/2

Y1 - 2011/2

N2 - BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.

AB - BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.

KW - rectal cancer

KW - radiotherapy

M3 - Article

SN - 1068-9265

VL - 18

SP - 380

EP - 385

JO - Ann Surg Oncol

JF - Ann Surg Oncol

IS - 2

ER -

Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer

Abstract

Keywords

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