Abstract
PURPOSE OF REVIEW: The prescription of proton pump inhibitors has an increasing trend, despite that guidelines recommend nutritional management as first-line management. A thickened antiregurgitation formula is recommended in formula-fed infants. In this review we focus on the novel insights in management of formula-fed infants with gastroesophageal reflux disease (GERD).
RECENT FINDINGS: New data are limited. Concerning thickened antiregurgitation formula, locust bean gum has been the most studied and has limited adverse effects. However, positive results were also obtained with pectin. The effect of pro- and prebiotics on regurgitation is unclear. The overlap between cow's milk allergy and gastroesophageal reflux remains a challenge.
SUMMARY: Very limited new data were published during the last 18 months. Thickened antiregurgitation formula is the first-line approach in formula-fed infants with GERD. No specific thickening agent can be recommended because of lack of comparative trials. Proton pump inhibitors are over prescribed in infants.
| Original language | English |
|---|---|
| Pages (from-to) | 503-509 |
| Number of pages | 7 |
| Journal | Current opinion in pediatrics |
| Volume | 34 |
| Issue number | 5 |
| Early online date | 19 Jul 2022 |
| DOIs | |
| Publication status | Published - Oct 2022 |
Bibliographical note
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.Keywords
- gastroesophageal reflux
- formula-fed infants
- nutrition