Projects per year
Abstract
Abstract
Herein we describe a catalyst-free procedure employing an Ugi-4CR between a beta-azido-alpha-amino acid, propargylamine, an isocyanide and an aldehyde, followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library of amino-triazoloazepinone-bearing di- and tripeptides with up to four points of diversification and high atom economy.
Herein we describe a catalyst-free procedure employing an Ugi-4CR between a beta-azido-alpha-amino acid, propargylamine, an isocyanide and an aldehyde, followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library of amino-triazoloazepinone-bearing di- and tripeptides with up to four points of diversification and high atom economy.
| Original language | English |
|---|---|
| Pages (from-to) | 6986-6989 |
| Number of pages | 4 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 12 |
| Publication status | Published - 2014 |
Keywords
- multicomponent reactions
Fingerprint
Dive into the research topics of 'Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi-Huisgen tandem reaction: IF 3.562'. Together they form a unique fingerprint.Projects
- 1 Finished
-
FWOAL570: Discovery of novel opioid analgesics based on the chemical modification of the lead compound Dmt1-DALDA
1/04/10 → 31/03/13
Project: Fundamental