Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology

Research output: Contribution to journalArticlepeer-review


Connexin hemichannels have long been considered as mere structural precursors for gap junctions. In the last decade, it has become clear that they also act as individual channels, connecting the intracellular compartment and the extracellular environment. Impairement of connexin hemichannel functionality may result in disturbance of homeostasis, as exemplified in the current paper for the intestine and the liver. Research in this field still has a number of shortcomings, of which some are also discussed here.
Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalWorld Journal of Gastrointestinal Pathophysiology
Publication statusPublished - 15 Oct 2010


  • connexin
  • hemichannel
  • gap junction


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