Encrusted Uropathy: A Comprehensive Overview-To the Bottom of the Crust

Els Van de Perre; Gina Reichman; Deborah De Geyter; Caroline Geers; Karl M Wissing; Emmanuel Letavernier

doi:10.3389/fmed.2020.609024

Encrusted Uropathy: A Comprehensive Overview-To the Bottom of the Crust

Els Van de Perre, Gina Reichman, Deborah De Geyter, Caroline Geers, Karl M Wissing, Emmanuel Letavernier

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Abstract

Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.

Original language	English
Article number	609024
Pages (from-to)	1-14
Number of pages	14
Journal	Frontiers in Medicine
Volume	7
DOIs	https://doi.org/10.3389/fmed.2020.609024
Publication status	Published - 21 Jan 2021

Bibliographical note

Keywords

Corynebacterium urealyticum
encrusted cystitis
encrusted pyelitis
encrusted uropathy
urease-producing bacteria

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10.3389/fmed.2020.609024Licence: CC BY

64310650Final published version, 3.04 MBLicence: CC BY

Cite this

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title = "Encrusted Uropathy: A Comprehensive Overview-To the Bottom of the Crust",

abstract = "Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.",

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AU - De Geyter, Deborah

AU - Geers, Caroline

AU - Wissing, Karl M

AU - Letavernier, Emmanuel

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Encrusted Uropathy: A Comprehensive Overview-To the Bottom of the Crust

Abstract

Bibliographical note

Keywords

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