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Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.

Original languageEnglish
Article number609024
Pages (from-to)1-14
Number of pages14
JournalFrontiers in Medicine
Publication statusPublished - 21 Jan 2021

Bibliographical note

Copyright © 2021 Van de Perre, Reichman, De Geyter, Geers, Wissing and Letavernier.


  • Corynebacterium urealyticum
  • encrusted cystitis
  • encrusted pyelitis
  • encrusted uropathy
  • urease-producing bacteria


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