Endocrine Disrupting Chemicals (EDCs): Estrogenic Activities of Indoor Dust in Kindergartens

Tara Vandermarken, Sandra De Galan, Joeri Vercammen, Kim Croes, Kersten Van Langenhove, Hermes Sanctorum-Vandevoorde, Michael Denison, Leo Goeyens, Marc Elskens, Willy Baeyens

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract (Book)

Abstract

Endocrine disrupting chemicals: Estrogenic activities of indoor dust in kindergartens

Vandermarken T. 1*, De Galan S.1, Vercammen J.2, Croes K.1, Van Langenhove K.1, Sanctorum H.1, Denison M.S.3, Goeyens L.1, Elskens E.1, Baeyens W.1

1. Vrije Universiteit Brussel, Department of Analytical, Environmental and Geo-Chemistry, Pleinlaan 2, 1050 Brussels, Belgium
2. Interscience, Avenue J.E. Lenoir 2, 1348 Louvain-la-Neuve, Belgium
3. Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, United States of America

* corresponding author
Tara Vandermarken
Tel: +32 (0)2 629 32 93
Fax: +32 (0)2 629 32 74
E-mail: [email protected]

Estrogen-like Endocrine Disrupting Chemicals (EEDCs) interfere with the synthesis, secretion, transport, metabolism, binding action, or elimination of natural blood-borne hormones. They bind onto estrogen receptors, mimicking or blocking the action of natural hormones.

By disrupting the endocrine system of an organism, many health problems can be provoked even in the following generations. Effects include a change in development, change in fertility, metabolic syndrome, diabetes, obesity, breast cancer and prostate cancer.

EEDCs are abundantly found as plasticizer (e.g. phthalates) or as flame retardants (e.g. PBDEs) in plastics (e.g. in toys). These non-chemically bound additives can easily migrate to the surrounding environment and attach to fine dust particles. For young children, indoor dust constitutes one of the major exposure routes.

Analyzing a dust sample by mass spectrometry (e.g. LC-MS or GC-MS) can become very expensive due to the large amount of possible EEDCs and cannot account for any antagonist or synergetic effects. Unknown EEDCs, still a very large group of components, cannot be measured by traditional analysis and can thereby not be included in a risk assessment.

Using the ERE-CALUX bioassay, a receptor based technique, solutions to these problems will be given by measuring an overall endocrine disrupting activity.
Original languageEnglish
Title of host publicationHTC-13 & HTSP-3
Publication statusPublished - 29 Jan 2014
Event13th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analysers, HTC-13 & HTSP-3 - Bruges, Belgium
Duration: 29 Jan 201431 Jan 2014

Conference

Conference13th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analysers, HTC-13 & HTSP-3
Country/TerritoryBelgium
CityBruges
Period29/01/1431/01/14

Keywords

  • EDC
  • CALUX
  • Dust
  • Phthalate

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